| Nome |
# |
|
KSHV dysregulates bulk macroautophagy, mitophagy and UPR to promote endothelial to mesenchymal transition and CCL2 release, key events in viral-driven sarcomagenesis, file e3835327-4d71-15e8-e053-a505fe0a3de9
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407
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|
Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits macrophage formation and survival by counteracting Macrophage Colony-Stimulating Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun N-terminal kinase (JNK) phosphorylation and autophagy, file e3835323-11ce-15e8-e053-a505fe0a3de9
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231
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|
Mutant p53, stabilized by its interplay with HSP90, activates a positive feed-back loop between NRF2 and p62 that induces chemio-resistance to Apigenin in pancreatic cancer cells, file e3835321-b068-15e8-e053-a505fe0a3de9
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144
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Zinc Supplementation Enhances the Pro-Death Function of UPR in Lymphoma Cells Exposed to Radiation, file e383532e-0e5e-15e8-e053-a505fe0a3de9
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136
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Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death, file e3835318-7d26-15e8-e053-a505fe0a3de9
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132
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Anticancer effect of AZD2461 PARP inhibitor against colon cancer cells carrying wt or dysfunctional p53, file e383532d-680b-15e8-e053-a505fe0a3de9
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116
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Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy, file e3835318-c290-15e8-e053-a505fe0a3de9
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114
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Cytotoxic drugs activate KSHV lytic cycle in latently infected PEL cells by inducing a moderate ROS increase controlled by HSF1, NRF2 and p62/SQSTM1, file e383531e-c48e-15e8-e053-a505fe0a3de9
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108
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Reduced chemotherapeutic sensitivity in high glucose condition: implication of antioxidant response, file e3835322-ba01-15e8-e053-a505fe0a3de9
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97
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P62/sqstm1/keap1/nrf2 axis reduces cancer cells death-sensitivity in response to zn(Ii)–curcumin complex, file e383532b-cf58-15e8-e053-a505fe0a3de9
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96
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Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences, file e3835324-7460-15e8-e053-a505fe0a3de9
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93
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Quercetin interrupts the positive feedback loop between STAT3 and IL-6, promotes autophagy, and reduces ROS, preventing EBV-driven B cell immortalization, file e3835324-7467-15e8-e053-a505fe0a3de9
|
90
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KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression, file e3835326-6e11-15e8-e053-a505fe0a3de9
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83
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EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation, file e3835327-15c7-15e8-e053-a505fe0a3de9
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82
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The dysregulation of autophagy and ER stress induced by HHV-6A infection activates pro-inflammatory pathways and promotes the release of inflammatory cytokines and cathepsin S by CNS cells, file e383532e-a077-15e8-e053-a505fe0a3de9
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82
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STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway, file e3835328-0c9d-15e8-e053-a505fe0a3de9
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77
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Viral Infection and Autophagy Dysregulation. The Case of HHV-6, EBV and KSHV, file e383532c-14bc-15e8-e053-a505fe0a3de9
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65
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Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross-talk with p53 to activate p21, file e383532d-2fa5-15e8-e053-a505fe0a3de9
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65
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Interplay between endoplasmic reticulum (ER) stress and autophagy induces mutant p53H273 degradation, file e3835325-088a-15e8-e053-a505fe0a3de9
|
60
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Ire1 alpha/xbp1 axis sustains primary effusion lymphoma cell survival by promoting cytokine release and stat3 activation, file e383532b-d37f-15e8-e053-a505fe0a3de9
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55
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Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression, file e3835329-64dc-15e8-e053-a505fe0a3de9
|
53
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p53-R273H Sustains ROS, Pro-Inflammatory Cytokine Release and mTOR Activation While Reducing Autophagy, Mitophagy and UCP2 Expression, Effects Prevented by wtp53, file e383532b-e9a7-15e8-e053-a505fe0a3de9
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50
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A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status, file e3835327-36d7-15e8-e053-a505fe0a3de9
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49
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Targeting c-Myc Unbalances UPR towards Cell Death and Impairs DDR in Lymphoma and Multiple Myeloma Cells, file e383532e-f15a-15e8-e053-a505fe0a3de9
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46
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PBA preferentially impairs cell survival of glioblastomas carrying mutp53 by reducing its expression level, stabilizing wtp53, downregulating the mevalonate kinase and dysregulating UPR, file e3835326-70d9-15e8-e053-a505fe0a3de9
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40
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Role of upr sensor activation in cell death–survival decision of colon cancer cells stressed by dpe treatment, file e383532d-19a0-15e8-e053-a505fe0a3de9
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37
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New insights into curcumin-and resveratrol-mediated anti-cancer effects, file e383532d-b031-15e8-e053-a505fe0a3de9
|
24
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c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway, file b716eae3-e354-409b-b9b9-094a01ad7485
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18
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VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor, file e383532e-46c9-15e8-e053-a505fe0a3de9
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16
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Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP. A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas, file fed84c75-28c8-4f10-b26f-9aa3acb540d5
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9
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ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress, file 20bb4c57-54d2-4dc5-a835-8cdd91aad607
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6
|
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KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression, file e383531e-793d-15e8-e053-a505fe0a3de9
|
6
|
|
The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice, file a9c6557a-f7ce-42fc-b136-8d4836e0a76a
|
5
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|
HSP110 Inhibition in Primary Effusion Lymphoma Cells. One Molecule, Many Pro-Survival Targets, file da48019e-7b06-488d-b5cd-3595dd258cdd
|
5
|
|
Engagement of CD4 before TCR triggering regulates both Bax- and Fas (CD95)-mediated apoptosis, file e3835311-8f10-15e8-e053-a505fe0a3de9
|
5
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Sodium butyrate sensitises human pancreatic cancer cells to both the intrinsic and the extrinsic apoptotic pathways., file e3835312-4b25-15e8-e053-a505fe0a3de9
|
5
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Apoptosis induction in T lymphocytes by HIV., file e3835312-4b27-15e8-e053-a505fe0a3de9
|
5
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Hydroxytyrosol-derived compounds: a basis for the creation of new pharmacological agents for cancer prevention and therapy, file e3835312-c51e-15e8-e053-a505fe0a3de9
|
5
|
|
Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways, file e3835316-928d-15e8-e053-a505fe0a3de9
|
5
|
|
Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress, file e383531e-a5b2-15e8-e053-a505fe0a3de9
|
5
|
|
HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease, file e3835325-088e-15e8-e053-a505fe0a3de9
|
5
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|
Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations., file e383532d-e752-15e8-e053-a505fe0a3de9
|
5
|
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Analysis of susceptibility of mature human T lymphocytes to dexamethasone-induced apoptosis., file e3835311-67f8-15e8-e053-a505fe0a3de9
|
4
|
|
EBV up-regulates PD-L1 on the surface of primary monocytes by increasing ROS and activating TLR signaling and STAT3, file e383531b-85c8-15e8-e053-a505fe0a3de9
|
4
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|
NFE2L2 and STAT3 converge on common targets to promote survival of primary lymphoma cells, file 5b8003ca-ff7a-46a2-aa9e-db5cdc1707cd
|
3
|
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Different outcome of targeting ERN1/IRE1 alpha and EIF2AK3/PERK in NSG mice engrafted with primary effusion lymphoma, file 5cfbe887-2dc5-433c-b4f6-1955dcba3990
|
3
|
|
Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2, file e3835311-a679-15e8-e053-a505fe0a3de9
|
3
|
|
Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via Cd91, file e3835312-f5e3-15e8-e053-a505fe0a3de9
|
3
|
|
Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells, file e3835316-a806-15e8-e053-a505fe0a3de9
|
3
|
|
Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells, file e3835318-8e4e-15e8-e053-a505fe0a3de9
|
3
|
|
HHV-6B reduces autophagy and induces ER stress in primary monocytes impairing their survival and differentiation into dendritic cells, file e3835324-6977-15e8-e053-a505fe0a3de9
|
3
|
|
PGE2 released by pancreatic cancer cells undergoing ER stress transfers the stress to DCs impairing their immune function, file e383532c-33fc-15e8-e053-a505fe0a3de9
|
3
|
|
p62/SQSTM1 promotes mitophagy and activates the NRF2-mediated antioxidant and anti-inflammatory response restraining EBV-driven B lymphocyte proliferation, file e383532f-272a-15e8-e053-a505fe0a3de9
|
3
|
|
ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition., file e3835312-4b22-15e8-e053-a505fe0a3de9
|
2
|
|
High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/β-catenin and p38 MAPK, file e383531f-a583-15e8-e053-a505fe0a3de9
|
2
|
|
KSHV dysregulates bulk macroautophagy, mitophagy and UPR to promote endothelial to mesenchymal transition and CCL2 release, key events in viral-driven sarcomagenesis, file e3835327-31a9-15e8-e053-a505fe0a3de9
|
2
|
|
The cross-talk between STAT1/STAT3 and ROS up-regulates PD-L1 and promotes the release of pro-inflammatory/immune suppressive cytokines in primary monocytes infected by HHV-6B, file e383532b-e9ad-15e8-e053-a505fe0a3de9
|
2
|
|
DNA damage triggers an interplay between wtp53 and c-Myc affecting lymphoma cell proliferation and Kaposi sarcoma herpesvirus replication, file e383532d-af51-15e8-e053-a505fe0a3de9
|
2
|
|
3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells, file e383532e-ef9b-15e8-e053-a505fe0a3de9
|
2
|
|
The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells, file e383532f-2659-15e8-e053-a505fe0a3de9
|
2
|
|
EBV infection of primary colonic epithelial cells causes inflammation, DDR and autophagy dysregulation, effects that may predispose to IBD and carcinogenesis, file 6e49333b-f838-445f-b551-3a6dec34cfe4
|
1
|
|
Mechanisms of sensitivity and resistance of primary effusion lymphoma to dimethyl fumarate (DMF), file 82fe48bd-66b4-4168-90af-de50ec1641cc
|
1
|
|
Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation, file e3835318-a493-15e8-e053-a505fe0a3de9
|
1
|
| Totale |
2.789 |