PENNACCHIETTI, VALERIA
PENNACCHIETTI, VALERIA
DIPARTIMENTO DI SCIENZE BIOCHIMICHE "ALESSANDRO ROSSI FANELLI"
A PDZ tandem repeat folds and unfolds via different pathways
2024 Pennacchietti, Valeria; di Matteo, Sara; Pagano, Livia; Toplek, Fran Bačić; Stegani, Bruno; Toto, Angelo; Toso, Julian; Puglisi, Elena; Capelli, Riccardo; Di Felice, Mariana; Malagrinò, Francesca; Camilloni, Carlo; Gianni, Stefano
A single buried cysteine acts as a hydrophobic stabilizer of a folding intermediate and transition state in the MATH domain of SPOP
2025 Pagano, Livia; Diop, Awa; Pennacchietti, Valeria; Di Felice, Mariana; Ventura, Eduarda S.; Toso, Julian; Toto, Angelo; Gianni, Stefano
Addressing the binding mechanism of the Meprin and TRAF-C hmology domain of the Speckle-Type POZ protein using protein engineering
2023 Diop, Awa; Pietrangeli, Paola; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano
Allosteric modulation of Grb2 drives ligand-dependent signal responses
2025 Di Felice, Mariana; Rolfi, Lucrezia Romana; Toso, Julian; Pennacchietti, Valeria; Ventura, Eduarda S.; Toto, Angelo; Tramutola, Antonella; Gianni, Stefano
An intramolecular energetic network regulates ligand recognition in a SH2 domain
2023 Nardella, Caterina; Pagano, Livia; Pennacchietti, Valeria; Felice, Mariana Di; Matteo, Sara Di; Diop, Awa; Malagrinò, Francesca; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo
Biophysical characterization of the binding mechanism between the MATH domain of SPOP and its physiological partners
2023 Diop, Awa; Pietrangeli, Paola; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano
Characterization of early and late transition states of the folding pathway of a SH2 domain
2022 Toto, Angelo; Malagrinò, Francesca; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Santorelli, Daniele; Diop, Awa; Gianni, Stefano
Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands
2023 Pennacchietti, Valeria; Pagano, Livia; Malagrinò, Francesca; Diop, Awa; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Pietrangeli, Paola; Toto, Angelo; Gianni, Stefano
Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat
2022 Malagrinò, Francesca; Fusco, Giuliana; Pennacchietti, Valeria; Toto, Angelo; Nardella, Caterina; Pagano, Livia; de Simone, Alfonso; Gianni, Stefano
Different electrostatic forces drive the binding kinetics of SARS-CoV, SARS-CoV-2 and MERS-CoV Envelope proteins with the PDZ2 domain of ZO1
2023 Pennacchietti, Valeria; Toto, Angelo
Exploring the effect of tethered domains on the folding of Grb2 protein
2022 Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Santorelli, Daniele; Pietrangeli, Paola; Marcocci, Lucia; Nardella, Caterina; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano
Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD
2024 Pagano, L.; Simonetti, L.; Pennacchietti, V.; Toto, A.; Malagrinò, F.; Ivarsson, Y.; Gianni, S.
Folding and binding kinetics of the tandem of SH2 domains from SHP2
2024 Pagano, Livia; Pennacchietti, Valeria; Malagrinò, Francesca; Di Felice, Mariana; Toso, Julian; Puglisi, Elena; Gianni, Stefano; Toto, Angelo
Folding and binding mechanisms of the SH2 domain from Crkl
2022 Nardella, Caterina; Toto, Angelo; Santorelli, Daniele; Pagano, Livia; Diop, Awa; Pennacchietti, Valeria; Pietrangeli, Paola; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano
Monomeric and dimeric states of human ZO1-PDZ2 are functional partners of the SARS-CoV-2 E protein
2023 Giacon, Noah; Lo Cascio, Ettore; Davidson, Darcy S.; Polêto, Marcelo D.; Lemkul, Justin A.; Pennacchietti, Valeria; Pagano, Livia; Zamparelli, Carlotta; Toto, Angelo; Arcovito, Alessandro
On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains
2022 Malagrino, F.; Pennacchietti, V.; Santorelli, D.; Pagano, L.; Nardella, C.; Diop, A.; Toto, A.; Gianni, S.
PDZ2-conjugated-PLGA nanoparticles are tiny heroes in the battle against SARS-CoV-2
2024 Giacon, Noah; Lo Cascio, Ettore; Pennacchietti, Valeria; De Maio, Flavio; Santarelli, Giulia; Sibilia, Diego; Tiberio, Federica; Sanguinetti, Maurizio; Lattanzi, Wanda; Toto, Angelo; Arcovito, Alessandro
Probing the effects of local frustration in the folding of a multidomain protein
2021 Pagano, Livia; Malagrinò, Francesca; Visconti, Lorenzo; Troilo, Francesca; Pennacchietti, Valeria; Nardella, Caterina; Toto, Angelo; Gianni, Stefano
SH2 Domains: folding, binding and therapeutical approaches
2022 Diop, Awa; Santorelli, Daniele; Malagrinò, Francesca; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo
The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain
2024 Di Felice, Mariana; Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Pietrangeli, Paola; Marcocci, Lucia; Di Matteo, Sara; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A PDZ tandem repeat folds and unfolds via different pathways | 2024 | Pennacchietti, Valeria; di Matteo, Sara; Pagano, Livia; Toplek, Fran Bačić; Stegani, Bruno; Toto, Angelo; Toso, Julian; Puglisi, Elena; Capelli, Riccardo; Di Felice, Mariana; Malagrinò, Francesca; Camilloni, Carlo; Gianni, Stefano | |
| A single buried cysteine acts as a hydrophobic stabilizer of a folding intermediate and transition state in the MATH domain of SPOP | 2025 | Pagano, Livia; Diop, Awa; Pennacchietti, Valeria; Di Felice, Mariana; Ventura, Eduarda S.; Toso, Julian; Toto, Angelo; Gianni, Stefano | |
| Addressing the binding mechanism of the Meprin and TRAF-C hmology domain of the Speckle-Type POZ protein using protein engineering | 2023 | Diop, Awa; Pietrangeli, Paola; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano | |
| Allosteric modulation of Grb2 drives ligand-dependent signal responses | 2025 | Di Felice, Mariana; Rolfi, Lucrezia Romana; Toso, Julian; Pennacchietti, Valeria; Ventura, Eduarda S.; Toto, Angelo; Tramutola, Antonella; Gianni, Stefano | |
| An intramolecular energetic network regulates ligand recognition in a SH2 domain | 2023 | Nardella, Caterina; Pagano, Livia; Pennacchietti, Valeria; Felice, Mariana Di; Matteo, Sara Di; Diop, Awa; Malagrinò, Francesca; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo | |
| Biophysical characterization of the binding mechanism between the MATH domain of SPOP and its physiological partners | 2023 | Diop, Awa; Pietrangeli, Paola; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano | |
| Characterization of early and late transition states of the folding pathway of a SH2 domain | 2022 | Toto, Angelo; Malagrinò, Francesca; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Santorelli, Daniele; Diop, Awa; Gianni, Stefano | |
| Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands | 2023 | Pennacchietti, Valeria; Pagano, Livia; Malagrinò, Francesca; Diop, Awa; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Pietrangeli, Paola; Toto, Angelo; Gianni, Stefano | |
| Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat | 2022 | Malagrinò, Francesca; Fusco, Giuliana; Pennacchietti, Valeria; Toto, Angelo; Nardella, Caterina; Pagano, Livia; de Simone, Alfonso; Gianni, Stefano | |
| Different electrostatic forces drive the binding kinetics of SARS-CoV, SARS-CoV-2 and MERS-CoV Envelope proteins with the PDZ2 domain of ZO1 | 2023 | Pennacchietti, Valeria; Toto, Angelo | |
| Exploring the effect of tethered domains on the folding of Grb2 protein | 2022 | Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Santorelli, Daniele; Pietrangeli, Paola; Marcocci, Lucia; Nardella, Caterina; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano | |
| Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD | 2024 | Pagano, L.; Simonetti, L.; Pennacchietti, V.; Toto, A.; Malagrinò, F.; Ivarsson, Y.; Gianni, S. | |
| Folding and binding kinetics of the tandem of SH2 domains from SHP2 | 2024 | Pagano, Livia; Pennacchietti, Valeria; Malagrinò, Francesca; Di Felice, Mariana; Toso, Julian; Puglisi, Elena; Gianni, Stefano; Toto, Angelo | |
| Folding and binding mechanisms of the SH2 domain from Crkl | 2022 | Nardella, Caterina; Toto, Angelo; Santorelli, Daniele; Pagano, Livia; Diop, Awa; Pennacchietti, Valeria; Pietrangeli, Paola; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano | |
| Monomeric and dimeric states of human ZO1-PDZ2 are functional partners of the SARS-CoV-2 E protein | 2023 | Giacon, Noah; Lo Cascio, Ettore; Davidson, Darcy S.; Polêto, Marcelo D.; Lemkul, Justin A.; Pennacchietti, Valeria; Pagano, Livia; Zamparelli, Carlotta; Toto, Angelo; Arcovito, Alessandro | |
| On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains | 2022 | Malagrino, F.; Pennacchietti, V.; Santorelli, D.; Pagano, L.; Nardella, C.; Diop, A.; Toto, A.; Gianni, S. | |
| PDZ2-conjugated-PLGA nanoparticles are tiny heroes in the battle against SARS-CoV-2 | 2024 | Giacon, Noah; Lo Cascio, Ettore; Pennacchietti, Valeria; De Maio, Flavio; Santarelli, Giulia; Sibilia, Diego; Tiberio, Federica; Sanguinetti, Maurizio; Lattanzi, Wanda; Toto, Angelo; Arcovito, Alessandro | |
| Probing the effects of local frustration in the folding of a multidomain protein | 2021 | Pagano, Livia; Malagrinò, Francesca; Visconti, Lorenzo; Troilo, Francesca; Pennacchietti, Valeria; Nardella, Caterina; Toto, Angelo; Gianni, Stefano | |
| SH2 Domains: folding, binding and therapeutical approaches | 2022 | Diop, Awa; Santorelli, Daniele; Malagrinò, Francesca; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo | |
| The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain | 2024 | Di Felice, Mariana; Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Pietrangeli, Paola; Marcocci, Lucia; Di Matteo, Sara; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano |