Chronic liver diseases in children represent a rising problem with significant effects on public health. In fact, several pediatric liver diseases are precursors of adult chronic hepatopathies, cirrhosis and hepatocellular carcinoma. The prevalence of liver diseases in children is unknown. In the USA, every year, 15,000 children are hospitalized for liver diseases, but these disorders continue to be under-recognized or diagnosed late. The main reason is due to the frequent absence of symptoms in the vast majority of liver diseases, especially in the early stages. In the last few decades several advances have been made in understanding the pathogenesis of liver diseases, permitting the discovery of new therapeutic targets to treat liver diseases, thus improving the natural history of these disorders. In this article we discuss the most recent advances in the understanding of the pathogenesis, diagnosis and treatment of the most frequent pediatric liver diseases.

Pediatric liver diseases: current challenges and future perspectives / Della Corte, Claudia; Mosca, Antonella; Vania, Andrea; Alterio, Arianna; Alisi, Anna; Nobili, Valerio. - In: EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY. - ISSN 1747-4124. - STAMPA. - 10:2(2016), pp. 255-265. [10.1586/17474124.2016.1129274]

Pediatric liver diseases: current challenges and future perspectives

Mosca, Antonella;Vania, Andrea;Alisi, Anna;Nobili, Valerio
2016

Abstract

Chronic liver diseases in children represent a rising problem with significant effects on public health. In fact, several pediatric liver diseases are precursors of adult chronic hepatopathies, cirrhosis and hepatocellular carcinoma. The prevalence of liver diseases in children is unknown. In the USA, every year, 15,000 children are hospitalized for liver diseases, but these disorders continue to be under-recognized or diagnosed late. The main reason is due to the frequent absence of symptoms in the vast majority of liver diseases, especially in the early stages. In the last few decades several advances have been made in understanding the pathogenesis of liver diseases, permitting the discovery of new therapeutic targets to treat liver diseases, thus improving the natural history of these disorders. In this article we discuss the most recent advances in the understanding of the pathogenesis, diagnosis and treatment of the most frequent pediatric liver diseases.
2016
children, liver disease, nonalcoholic fatty liver disease, treatment, chronic viral hepatitis, Wilson disease, autoimmune hepatitis
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Pediatric liver diseases: current challenges and future perspectives / Della Corte, Claudia; Mosca, Antonella; Vania, Andrea; Alterio, Arianna; Alisi, Anna; Nobili, Valerio. - In: EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY. - ISSN 1747-4124. - STAMPA. - 10:2(2016), pp. 255-265. [10.1586/17474124.2016.1129274]
File allegati a questo prodotto
File Dimensione Formato  
Della Corte_ Pediatric liver disease_2016.pdf

accesso aperto

Note: articolo principale
Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.01 MB
Formato Adobe PDF
1.01 MB Adobe PDF
Della Corte_Pediatric liver diseases_2016.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 7.73 MB
Formato Adobe PDF
7.73 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/972913
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 17
social impact