Cell therapy of liver diseases with human biliary tree stem cells (hBTSCs) is biased by low engraftment efficiency. Coating the hBTSCs with hyaluronans (HAs), the primary constituents of all stem cell niches, could facilitate cell survival, proliferation, and, specifically, liver engraftment given that HAs are cleared selectively by the liver.
Hyaluronan coating improves liver engraftment of transplanted human biliary tree stem/progenitor cells / Nevi, Lorenzo; Carpino, Guido; Costantini, Daniele; Cardinale, Vincenzo; Riccioni, Olga; DI MATTEO, Sabina; Melandro, Fabio; Berloco, Pasquale Bartolomeo; Reid, Lola; Gaudio, Eugenio; Alvaro, Domenico. - In: STEM CELL RESEARCH & THERAPY. - ISSN 1757-6512. - 8:1(2017). [10.1186/s13287-017-0492-7]
Hyaluronan coating improves liver engraftment of transplanted human biliary tree stem/progenitor cells
NEVI, LORENZO;Carpino, Guido;COSTANTINI, DANIELE;CARDINALE, VINCENZO;DI MATTEO, SABINA;MELANDRO, FABIO;BERLOCO, Pasquale Bartolomeo;GAUDIO, EUGENIO;ALVARO, Domenico
2017
Abstract
Cell therapy of liver diseases with human biliary tree stem cells (hBTSCs) is biased by low engraftment efficiency. Coating the hBTSCs with hyaluronans (HAs), the primary constituents of all stem cell niches, could facilitate cell survival, proliferation, and, specifically, liver engraftment given that HAs are cleared selectively by the liver.| File | Dimensione | Formato | |
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