During the last decades, therapies targeting cervical cancer have been considerably improved. Surgery and radiotherapy (RT) represent the main common therapeutic approach in cervical cancer. In order to minimize the side effects of radiotherapy approach, several protocols have been developed such as brachytherapy (BRT). Among the side effects associated with RT, the vaginal atrophy is the most important and common one. Vaginal atrophy, in turn, leads to additional alterations like inflammation, associated to relevant symptoms such as itching, burning and dyspareunia. All these alterations heavily affect the quality of women's life. The aim of our study was to evaluate the toxicity induced by RT on vaginal mucosa, and the adjuvant action of a product containing LMWHA, vitamin A, and Vitamin E (Santes®, Lo.Li. Pharma, Rome, Italy). The introduction of adjuvant therapies may have likely had a relevant place in providing that result.

Hyaluronic acid and vitamins are effective in reducing vaginal atrophy in women receiving radiotherapy / Dinicola, S; Pasta, V; Costantino, D; Guaraldi, C; Bizzarri, Mariano. - In: MINERVA GINECOLOGICA. - ISSN 1827-1650. - 67:6(2015), pp. 523-531.

Hyaluronic acid and vitamins are effective in reducing vaginal atrophy in women receiving radiotherapy

BIZZARRI, Mariano
2015

Abstract

During the last decades, therapies targeting cervical cancer have been considerably improved. Surgery and radiotherapy (RT) represent the main common therapeutic approach in cervical cancer. In order to minimize the side effects of radiotherapy approach, several protocols have been developed such as brachytherapy (BRT). Among the side effects associated with RT, the vaginal atrophy is the most important and common one. Vaginal atrophy, in turn, leads to additional alterations like inflammation, associated to relevant symptoms such as itching, burning and dyspareunia. All these alterations heavily affect the quality of women's life. The aim of our study was to evaluate the toxicity induced by RT on vaginal mucosa, and the adjuvant action of a product containing LMWHA, vitamin A, and Vitamin E (Santes®, Lo.Li. Pharma, Rome, Italy). The introduction of adjuvant therapies may have likely had a relevant place in providing that result.
2015
Adult; Atrophy; Brachytherapy; Combined Modality Therapy; Female; Humans; Hyaluronic Acid; Middle Aged; Pilot Projects; Prospective Studies; Radiation Injuries; Treatment Outcome; Uterine Cervical Neoplasms; Vaginal Diseases; Vitamin A; Vitamin E; Vitamins; Young Adult
01 Pubblicazione su rivista::01a Articolo in rivista
Hyaluronic acid and vitamins are effective in reducing vaginal atrophy in women receiving radiotherapy / Dinicola, S; Pasta, V; Costantino, D; Guaraldi, C; Bizzarri, Mariano. - In: MINERVA GINECOLOGICA. - ISSN 1827-1650. - 67:6(2015), pp. 523-531.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/945315
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