Conformational analysis of antiparallel double-helical polynucleotides with Watson-Crick base pairing was reduced to a 4-dimensional problem using original math. methods. In the 4-dimensional conformational space, the family of structures, characterized by the base-pair stacking with the most stable conformations in water soln. as well as in the solid state, was localized. For the C2'-endo sugar pucker, both right-handed and left-handed structures were found; right-handed structures only, however, appear to be allowed for the C3'-endo pucker, the only possible one for ribonucleotides with base stacking.
Conformational and structural constraints in double-helical polynucleotides / DE SANTIS, Pasquale; Morosetti, Stefano; Palleschi, Antonio; Savino, Maria. - In: BIOPOLYMERS. - ISSN 0006-3525. - STAMPA. - 20:8(1981), pp. 1707-1725. [10.1002/bip.1981.360200811]
Conformational and structural constraints in double-helical polynucleotides
DE SANTIS, Pasquale;MOROSETTI, Stefano;PALLESCHI, Antonio;SAVINO, Maria
1981
Abstract
Conformational analysis of antiparallel double-helical polynucleotides with Watson-Crick base pairing was reduced to a 4-dimensional problem using original math. methods. In the 4-dimensional conformational space, the family of structures, characterized by the base-pair stacking with the most stable conformations in water soln. as well as in the solid state, was localized. For the C2'-endo sugar pucker, both right-handed and left-handed structures were found; right-handed structures only, however, appear to be allowed for the C3'-endo pucker, the only possible one for ribonucleotides with base stacking.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.