Conformational analysis of antiparallel double-helical polynucleotides with Watson-Crick base pairing was reduced to a 4-dimensional problem using original math. methods. In the 4-dimensional conformational space, the family of structures, characterized by the base-pair stacking with the most stable conformations in water soln. as well as in the solid state, was localized. For the C2'-endo sugar pucker, both right-handed and left-handed structures were found; right-handed structures only, however, appear to be allowed for the C3'-endo pucker, the only possible one for ribonucleotides with base stacking.

Conformational and structural constraints in double-helical polynucleotides / DE SANTIS, Pasquale; Morosetti, Stefano; Palleschi, Antonio; Savino, Maria. - In: BIOPOLYMERS. - ISSN 0006-3525. - STAMPA. - 20:8(1981), pp. 1707-1725. [10.1002/bip.1981.360200811]

Conformational and structural constraints in double-helical polynucleotides

DE SANTIS, Pasquale;MOROSETTI, Stefano;PALLESCHI, Antonio;SAVINO, Maria
1981

Abstract

Conformational analysis of antiparallel double-helical polynucleotides with Watson-Crick base pairing was reduced to a 4-dimensional problem using original math. methods. In the 4-dimensional conformational space, the family of structures, characterized by the base-pair stacking with the most stable conformations in water soln. as well as in the solid state, was localized. For the C2'-endo sugar pucker, both right-handed and left-handed structures were found; right-handed structures only, however, appear to be allowed for the C3'-endo pucker, the only possible one for ribonucleotides with base stacking.
1981
4-dimensional conformational space; antiparallel double-helical polynucleotides; molecular models; sugar pucker in nucleic acids
01 Pubblicazione su rivista::01a Articolo in rivista
Conformational and structural constraints in double-helical polynucleotides / DE SANTIS, Pasquale; Morosetti, Stefano; Palleschi, Antonio; Savino, Maria. - In: BIOPOLYMERS. - ISSN 0006-3525. - STAMPA. - 20:8(1981), pp. 1707-1725. [10.1002/bip.1981.360200811]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/382525
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