Actinic Keratosis Pathogenesis Update and New Patents

Background Actinic keratosis is a common premalignant skin lesion. Because of increasing incidence of actinic keratosis, several efforts have been done to detect earlier this premalignant lesion and to improve knowledge on photocarcinogenic pathways of keratinocytes. As a consequence, new discoveries have been done in this field recently. Objective Starting from our previous review on actinic keratosis, we reviewed the literature abo this premalignant lesion, focusing on pathogenesis and new patents for its early diagnosis, in order to highlight the most recent progresses in diagnosis and therapeutic approach of actinic keratosis. Conclusion Although several efforts have been done in the field of actinic keratosis, new upgrades in diagnosis and therapy are needed to detect superficial actinic keratosis earlier, to improve the disease free survival of patient and to threat better the field cancerization.