A general method is described in which the harmonic analysis of perturbations is applied to the study of superstructures of macromolecular chains. The theoretical approach employed has been to apply harmonic perturbations on the conformational parameters in macromolecular helices of various periodicities and to study the overall variation in structure and its dependency on the periodicity of the perturbation. The results clearly show that when these perturbations do not contain harmonics close to the fundamental periodicities of the polymer chain, the consequent structural effects remain localized and are not productive at a superstructural level. Furthermore, the features of these superstructures are dependent only on the amplitude of the fundamental periodicity component of the perturbation and are generated by topologically equivalent transformations. These findings enable us to devise a model to study and identify transconformational pathways leading to global variations in the structure of the macromolecular chain.
Emergence of superstructures in Biopolymers / DE SANTIS, Pasquale; M., Fua'. - In: BERICHTE DER BUNSEN-GESELLSCHAFT. - ISSN 0940-483X. - STAMPA. - 98:(1994), pp. 1194-1197. [10.1002/bbpc.19940980925]
Emergence of superstructures in Biopolymers
DE SANTIS, Pasquale;
1994
Abstract
A general method is described in which the harmonic analysis of perturbations is applied to the study of superstructures of macromolecular chains. The theoretical approach employed has been to apply harmonic perturbations on the conformational parameters in macromolecular helices of various periodicities and to study the overall variation in structure and its dependency on the periodicity of the perturbation. The results clearly show that when these perturbations do not contain harmonics close to the fundamental periodicities of the polymer chain, the consequent structural effects remain localized and are not productive at a superstructural level. Furthermore, the features of these superstructures are dependent only on the amplitude of the fundamental periodicity component of the perturbation and are generated by topologically equivalent transformations. These findings enable us to devise a model to study and identify transconformational pathways leading to global variations in the structure of the macromolecular chain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.