Nineteen patients (16 men and 3 women, mean age 51 years) with previous anterior myocardial infarction and severe stenosis (> or = 90%) of the left anterior descending coronary artery were studied by magnetic resonance imaging (MRI) without and with contrast media to verify the capability of MRI in identifying viable myocardium in areas of severe systolic dysfunction. In corresponding left ventricular segments, a comparison was made between regional signal intensities (SI) determined on MRI images before and 4, 8, 12, and 30 minutes after administration of paramagnetic contrast media (gadolinium diethylenetriaminepentaacetic acid, 0.4 mmol/kg intravenously) and metabolic parameters determined by iodine 123 phenylpentadecanoic acid (IPPA) scintigraphy. The SI and the time of maximum postcontrast enhancement were analyzed by dividing the left ventricle into 11 segments. Each segment was classified as normal (group 1, n = 116), hibernating (group 2, n = 50), or necrotic (group 3, n = 43) on the basis of the IPPA washout rate (> 30%, 10% to 30%, and < 10%, respectively). Regional SI demonstrated significant differences in absolute values at 12 minutes (group 3: 1.62 +/- 0.58 vs group 1: 1.32 +/- 0.52, p < 0.01, and vs group 2: 1.34 +/- 0.48, p < 0.05) and at 30 minutes (group 3: 1.71 +/- 0.47 vs group 1: 1.21 +/- 0.55, p < 0.01, and vs group 2: 1.49 +/- 0.57, p < 0.05) and in temporal distribution. These results suggest that MRI has a potential role in differentiating viable from necrotic myocardium in patients with chronic severe systolic dysfunction.

Identification of viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction: role of MRI / Fedele, Francesco; Montesano, Teresa; FERRO LUZZI, Manfredi; DI CESARE, E; DI RENZI, P; Scopinaro, Francesco; Banci, M; Testa, A; Vitarelli, Antonino; Dagianti, Armando. - In: AMERICAN HEART JOURNAL. - ISSN 0002-8703. - STAMPA. - 128:3(1994), pp. 484-489. [10.1016/0002-8703(94)90621-1]

Identification of viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction: role of MRI.

FEDELE, Francesco;MONTESANO, Teresa;FERRO LUZZI, Manfredi;SCOPINARO, Francesco;VITARELLI, Antonino;DAGIANTI, Armando
1994

Abstract

Nineteen patients (16 men and 3 women, mean age 51 years) with previous anterior myocardial infarction and severe stenosis (> or = 90%) of the left anterior descending coronary artery were studied by magnetic resonance imaging (MRI) without and with contrast media to verify the capability of MRI in identifying viable myocardium in areas of severe systolic dysfunction. In corresponding left ventricular segments, a comparison was made between regional signal intensities (SI) determined on MRI images before and 4, 8, 12, and 30 minutes after administration of paramagnetic contrast media (gadolinium diethylenetriaminepentaacetic acid, 0.4 mmol/kg intravenously) and metabolic parameters determined by iodine 123 phenylpentadecanoic acid (IPPA) scintigraphy. The SI and the time of maximum postcontrast enhancement were analyzed by dividing the left ventricle into 11 segments. Each segment was classified as normal (group 1, n = 116), hibernating (group 2, n = 50), or necrotic (group 3, n = 43) on the basis of the IPPA washout rate (> 30%, 10% to 30%, and < 10%, respectively). Regional SI demonstrated significant differences in absolute values at 12 minutes (group 3: 1.62 +/- 0.58 vs group 1: 1.32 +/- 0.52, p < 0.01, and vs group 2: 1.34 +/- 0.48, p < 0.05) and at 30 minutes (group 3: 1.71 +/- 0.47 vs group 1: 1.21 +/- 0.55, p < 0.01, and vs group 2: 1.49 +/- 0.57, p < 0.05) and in temporal distribution. These results suggest that MRI has a potential role in differentiating viable from necrotic myocardium in patients with chronic severe systolic dysfunction.
1994
viable myocardium; coronary artery disease; left ventricular dysfunction; MRI.
01 Pubblicazione su rivista::01a Articolo in rivista
Identification of viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction: role of MRI / Fedele, Francesco; Montesano, Teresa; FERRO LUZZI, Manfredi; DI CESARE, E; DI RENZI, P; Scopinaro, Francesco; Banci, M; Testa, A; Vitarelli, Antonino; Dagianti, Armando. - In: AMERICAN HEART JOURNAL. - ISSN 0002-8703. - STAMPA. - 128:3(1994), pp. 484-489. [10.1016/0002-8703(94)90621-1]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/82768
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 29
social impact