NGF is implicated in retinal damage regression. To study whether this is a direct effect or an effect mediated by NGF on other endogenous biological mediators, we investigated the effect of exogenous administration of NGF in RCS rats affected by retinitis pigmentosa. We found that NGF administration exerts a rescue effect on photoreceptors in this animal model. NGF injection enhances brain-derived neurotrophic factor, beta-fibroblast growth factor, transforming growth factor-beta, vascular endothelial factor and neuropeptide-Y. This suggests that NGF has an effect on RCS rat retina, probably also through the stimulation of other biological mediators produced and released in the retina.
Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa / Lenzi, Laura; Coassin, Marco; Lambiase, Alessandro; Bonini, Stefano; Amendola, Tiziana; Aloe, Luigi. - In: VISION RESEARCH. - ISSN 0042-6989. - STAMPA. - 45:12(2005), pp. 1491-1500. [10.1016/j.visres.2004.12.020]
Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa
LAMBIASE, ALESSANDRO;
2005
Abstract
NGF is implicated in retinal damage regression. To study whether this is a direct effect or an effect mediated by NGF on other endogenous biological mediators, we investigated the effect of exogenous administration of NGF in RCS rats affected by retinitis pigmentosa. We found that NGF administration exerts a rescue effect on photoreceptors in this animal model. NGF injection enhances brain-derived neurotrophic factor, beta-fibroblast growth factor, transforming growth factor-beta, vascular endothelial factor and neuropeptide-Y. This suggests that NGF has an effect on RCS rat retina, probably also through the stimulation of other biological mediators produced and released in the retina.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
