We found that PPI-users had a higher rate and BBs-users a lower rate of infections. The lower infection rate and better prognosis of BB-users can not be attributed, as suggested by Schiavon et al., to a higher proportion of variceal bleeding in this group; in fact, the large majority of patients hospitalized for bleeding were excluded from the study as they came to our ward already on systemic antibiotic treatment (which is usually started in the Emergency room) and this would have represented a confounding factor. Only few patients with variceal bleeding were included: they developed bleeding after enrolment and were equally distributed between those taking and not taking BBs. Following the recent debate about the ‘therapeutic window’ of BBs in cirrhotic patients (2–4), we were also interested in evaluating possible harmful effects of BBs in cirrhotic patients with infections. This was a secondary aim of our study and we certainly recognize that the study was underpowered for this purpose.

Beta-blokers in patients with cirrhosis and infection: don't blame too soon / Merli, Manuela; Lucidi, Cristina; Venditti, Mario; Riggio, Oliviero. - In: LIVER INTERNATIONAL. - ISSN 1478-3223. - STAMPA. - 35:6(2015), pp. 1778-1779. [10.1111/liv.12812]

Beta-blokers in patients with cirrhosis and infection: don't blame too soon.

MERLI, Manuela;LUCIDI, CRISTINA;VENDITTI, Mario;RIGGIO, Oliviero
2015

Abstract

We found that PPI-users had a higher rate and BBs-users a lower rate of infections. The lower infection rate and better prognosis of BB-users can not be attributed, as suggested by Schiavon et al., to a higher proportion of variceal bleeding in this group; in fact, the large majority of patients hospitalized for bleeding were excluded from the study as they came to our ward already on systemic antibiotic treatment (which is usually started in the Emergency room) and this would have represented a confounding factor. Only few patients with variceal bleeding were included: they developed bleeding after enrolment and were equally distributed between those taking and not taking BBs. Following the recent debate about the ‘therapeutic window’ of BBs in cirrhotic patients (2–4), we were also interested in evaluating possible harmful effects of BBs in cirrhotic patients with infections. This was a secondary aim of our study and we certainly recognize that the study was underpowered for this purpose.
2015
cirrhosis, infection, proton pump inhibitor.
01 Pubblicazione su rivista::01a Articolo in rivista
Beta-blokers in patients with cirrhosis and infection: don't blame too soon / Merli, Manuela; Lucidi, Cristina; Venditti, Mario; Riggio, Oliviero. - In: LIVER INTERNATIONAL. - ISSN 1478-3223. - STAMPA. - 35:6(2015), pp. 1778-1779. [10.1111/liv.12812]
File allegati a questo prodotto
File Dimensione Formato  
Merli_Beta-blockers-patients-cirrhosis_2015.pdf

accesso aperto

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 156.75 kB
Formato Adobe PDF
156.75 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/780376
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact