We designed a 3-month open label trial of melatonin prophylaxis in children with primary headache. After a one month baseline period without receiving preventive drugs, all children received a 3-month course of melatonin, 3 mg, administered orally, at bedtime. A total of 22 children were enrolled (10 boys, mean age 12.2 +/- 2.6 years, age range 6 - 16 years), 13 had recurrent migraine without aura, 1 with aura and 8 had chronic tension-type headache. When the trial ended, 14 of the 21 subjects reported that the headache attacks had decreased by more than 50% in respect to baseline and 4 of them reported having no headache attacks. After receiving melatonin for one month one subject dropped out because of excessive daytime sleepiness. Our promising results warrant randomized placebo-controlled trials in children to assess the real effectiveness of melatonin in preventing primary headache.

Melatonin to prevent migraine or tension-type headache in children / Silvia, Miano; Parisi, Pasquale; Andrea, Pelliccia; Anna, Luchetti; Paolino, MARIA CHIARA; Villa, MARIA PIA. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 29:4(2008), pp. 285-287. [10.1007/s10072-008-0983-5]

Melatonin to prevent migraine or tension-type headache in children

PARISI, Pasquale;PAOLINO, MARIA CHIARA;VILLA, MARIA PIA
2008

Abstract

We designed a 3-month open label trial of melatonin prophylaxis in children with primary headache. After a one month baseline period without receiving preventive drugs, all children received a 3-month course of melatonin, 3 mg, administered orally, at bedtime. A total of 22 children were enrolled (10 boys, mean age 12.2 +/- 2.6 years, age range 6 - 16 years), 13 had recurrent migraine without aura, 1 with aura and 8 had chronic tension-type headache. When the trial ended, 14 of the 21 subjects reported that the headache attacks had decreased by more than 50% in respect to baseline and 4 of them reported having no headache attacks. After receiving melatonin for one month one subject dropped out because of excessive daytime sleepiness. Our promising results warrant randomized placebo-controlled trials in children to assess the real effectiveness of melatonin in preventing primary headache.
2008
children; headache; melatonin; migraine; prophylaxis; treatment
01 Pubblicazione su rivista::01a Articolo in rivista
Melatonin to prevent migraine or tension-type headache in children / Silvia, Miano; Parisi, Pasquale; Andrea, Pelliccia; Anna, Luchetti; Paolino, MARIA CHIARA; Villa, MARIA PIA. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 29:4(2008), pp. 285-287. [10.1007/s10072-008-0983-5]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/75737
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 22
  • Scopus 88
  • ???jsp.display-item.citation.isi??? 77
social impact