This study describes the reversible smooth muscle relaxant activities of an alcoholic extract of Hydrastis canadensis L. on rat uterine preparations and guinea-pig trachea. In the non-pregnant rat uterus the extract inhibited the amplitude of rhythmic spontaneous contractions (IC50 10 +/- 3.07 mu g/mL) and of contractions induced by 5HT (IC50 19.9 +/- 3.87 mu g/mL), oxytocin (IC50 10.5 +/- 0.37 mu g/mL) and acetylcholine (IC50 9.95 +/- 1.77 mu g/mL). The extract also relaxed carbachol precontracted guinea-pig trachea (EC50 1.6 +/- 0.943 mu g/mL). Timolol partially antagonized this effect on trachea strips (EC50 5.28 +/- 0.653 mu g/ mt) suggesting that the extract produces relaxation by beta-adrenoceptor-dependent and -independent mechanisms.
Spasmolytic activities of Hydrastis canadensis L. on rat uterus and guinea-pig trachea / M. F., Cometa; H., ABDEL HAQ; Palmery, Maura. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - STAMPA. - 12:(1998), pp. 83-85. [10.1002/(SICI)1099-1573(1998)12:1+<S83::AID-PTR258>3.0.CO;2-O]
Spasmolytic activities of Hydrastis canadensis L. on rat uterus and guinea-pig trachea
PALMERY, Maura
1998
Abstract
This study describes the reversible smooth muscle relaxant activities of an alcoholic extract of Hydrastis canadensis L. on rat uterine preparations and guinea-pig trachea. In the non-pregnant rat uterus the extract inhibited the amplitude of rhythmic spontaneous contractions (IC50 10 +/- 3.07 mu g/mL) and of contractions induced by 5HT (IC50 19.9 +/- 3.87 mu g/mL), oxytocin (IC50 10.5 +/- 0.37 mu g/mL) and acetylcholine (IC50 9.95 +/- 1.77 mu g/mL). The extract also relaxed carbachol precontracted guinea-pig trachea (EC50 1.6 +/- 0.943 mu g/mL). Timolol partially antagonized this effect on trachea strips (EC50 5.28 +/- 0.653 mu g/ mt) suggesting that the extract produces relaxation by beta-adrenoceptor-dependent and -independent mechanisms.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.