Micellar systems are widely applied as reactors to encapsulate inorganic nanoparticles in polymeric materials. However, only low inorganic contents and microscale dimensions are often achieved. The adsorption of albumin protein on ferrite nanoparticles permits to increase the stability of inorganic dispersions in water by inhibiting particle flocculation. Subsequent glutaraldehyde addition induces protein crosslinking and ferrite entrapment. Polymer–ferrite composite nanoparticles were obtained in this way. The magnetic albumin nanoparticles (25 nm mean diameter) obtained contain about 40wt% of ferrite and show superparamagnetic behaviour. The composite powder was successfully functionalized with amodel drug and the biological activity was evaluated.
Preparation of albumin-ferrite superparamagnetic nanoparticles using reverse micelles / Bellusci, Mariangela; Aurelio La, Barbera; Luca, Seralessandri; Franco, Padella; Piozzi, Antonella; Francesca, Varsano. - In: POLYMER INTERNATIONAL. - ISSN 0959-8103. - STAMPA. - 58:10(2009), pp. 1142-1147. [10.1002/pi.2642]
Preparation of albumin-ferrite superparamagnetic nanoparticles using reverse micelles
BELLUSCI, Mariangela;PIOZZI, Antonella;
2009
Abstract
Micellar systems are widely applied as reactors to encapsulate inorganic nanoparticles in polymeric materials. However, only low inorganic contents and microscale dimensions are often achieved. The adsorption of albumin protein on ferrite nanoparticles permits to increase the stability of inorganic dispersions in water by inhibiting particle flocculation. Subsequent glutaraldehyde addition induces protein crosslinking and ferrite entrapment. Polymer–ferrite composite nanoparticles were obtained in this way. The magnetic albumin nanoparticles (25 nm mean diameter) obtained contain about 40wt% of ferrite and show superparamagnetic behaviour. The composite powder was successfully functionalized with amodel drug and the biological activity was evaluated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
