Glucocorticoid hormones are known to act synergistically with other stress-activated neuromodulatory systems, such as norepinephrine and corticotropin-releasing factor (CRF), within the basolateral complex of the amygdala (BLA) to induce optimal strengthening of the consolidation of long-term memory of emotionally arousing experiences. However, as the onset of these glucocorticoid actions appear often too rapid to be explained by genomic regulation, the neurobiological mechanism of how glucocorticoids could modify the memory-enhancing properties of norepinephrine and CRF remained elusive. Here, we show that the endocannabinoid system, a rapidly activated retrograde messenger system, is a primary route mediating the actions of glucocorticoids, via a glucocorticoid receptor on the cell surface, on BLA neural plasticity and memory consolidation. Furthermore, glucocorticoids recruit downstream endocannabinoid activity within the BLA to interact with both the norepinephrine and CRF systems in enhancing memory consolidation. These findings have important implications for understanding the fine-tuned crosstalk between multiple stress hormone systems in the coordination of (mal)adaptive stress and emotional arousal effects on neural plasticity and memory consolidation.

Endocannabinoid signaling within the basolateral amygdala integrates multiple stress hormone effects on memory consolidation / Piray, Atsak; Daniela, Hauer; Campolongo, Patrizia; Gustav, Schelling; Raquel V., Fornari; Benno, Roozendaal. - In: NEUROPSYCHOPHARMACOLOGY. - ISSN 0893-133X. - STAMPA. - 6:40(2015), pp. 1485-1494. [doi: 10.1038/npp.2014.334.]

Endocannabinoid signaling within the basolateral amygdala integrates multiple stress hormone effects on memory consolidation

CAMPOLONGO, Patrizia;
2015

Abstract

Glucocorticoid hormones are known to act synergistically with other stress-activated neuromodulatory systems, such as norepinephrine and corticotropin-releasing factor (CRF), within the basolateral complex of the amygdala (BLA) to induce optimal strengthening of the consolidation of long-term memory of emotionally arousing experiences. However, as the onset of these glucocorticoid actions appear often too rapid to be explained by genomic regulation, the neurobiological mechanism of how glucocorticoids could modify the memory-enhancing properties of norepinephrine and CRF remained elusive. Here, we show that the endocannabinoid system, a rapidly activated retrograde messenger system, is a primary route mediating the actions of glucocorticoids, via a glucocorticoid receptor on the cell surface, on BLA neural plasticity and memory consolidation. Furthermore, glucocorticoids recruit downstream endocannabinoid activity within the BLA to interact with both the norepinephrine and CRF systems in enhancing memory consolidation. These findings have important implications for understanding the fine-tuned crosstalk between multiple stress hormone systems in the coordination of (mal)adaptive stress and emotional arousal effects on neural plasticity and memory consolidation.
2015
induced noradrenergic activation; glucocorticoids interact; feedback inhibition; enhance memory; system; modulation; disorder; arousal; transmission; cannabinoids
01 Pubblicazione su rivista::01a Articolo in rivista
Endocannabinoid signaling within the basolateral amygdala integrates multiple stress hormone effects on memory consolidation / Piray, Atsak; Daniela, Hauer; Campolongo, Patrizia; Gustav, Schelling; Raquel V., Fornari; Benno, Roozendaal. - In: NEUROPSYCHOPHARMACOLOGY. - ISSN 0893-133X. - STAMPA. - 6:40(2015), pp. 1485-1494. [doi: 10.1038/npp.2014.334.]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/656695
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