The dosage effect of Y-chromosome heterochromatin on suppression of position effect variegation (PEV) has long been well-known in Drosophila. The phenotypic effects of increasing the overall dosage of Y heterochromatin have also been demonstrated; hyperploidy of the Y chromosome produces male sterility and many somatic defects including variegation and abnormal legs and wings. This work addresses whether the suppression of Position Effect Variegation is a general feature of the heterochromatin (independent of the chromosome of origin) and whether a hyperdosage of heterochromatin can affect viability. The results show that the suppression of PEV is a general feature of any type of constitutive heterochromatin and that the intensity of suppression depends on its amount instead of some mappable factor on it. We also describe a clear dosage effect of Y heterochromatin on the viability of otherwise wild-type embryos and the modification of that effect by a specific gene mutation. Together, our results indicate that the correct balance between heterochromatin and euchromatin is essential for the normal genome expression and that this balance is genetically controlled. Copyright © 2014 Author et al.

Position Effect Variegation and Viability Are Both Sensitive to Dosage of Constitutive Heterochromatin in Drosophila / M., Berloco; G., Palumbo; Piacentini, Lucia; Pimpinelli, Sergio; Fanti, Laura. - In: G3. - ISSN 2160-1836. - STAMPA. - 4:9(2014), pp. 1709-1716. [10.1534/g3.114.013045]

Position Effect Variegation and Viability Are Both Sensitive to Dosage of Constitutive Heterochromatin in Drosophila.

PIACENTINI, Lucia;PIMPINELLI, Sergio;FANTI, Laura
2014

Abstract

The dosage effect of Y-chromosome heterochromatin on suppression of position effect variegation (PEV) has long been well-known in Drosophila. The phenotypic effects of increasing the overall dosage of Y heterochromatin have also been demonstrated; hyperploidy of the Y chromosome produces male sterility and many somatic defects including variegation and abnormal legs and wings. This work addresses whether the suppression of Position Effect Variegation is a general feature of the heterochromatin (independent of the chromosome of origin) and whether a hyperdosage of heterochromatin can affect viability. The results show that the suppression of PEV is a general feature of any type of constitutive heterochromatin and that the intensity of suppression depends on its amount instead of some mappable factor on it. We also describe a clear dosage effect of Y heterochromatin on the viability of otherwise wild-type embryos and the modification of that effect by a specific gene mutation. Together, our results indicate that the correct balance between heterochromatin and euchromatin is essential for the normal genome expression and that this balance is genetically controlled. Copyright © 2014 Author et al.
2014
heterochromatin; viability; drosophila; pev
01 Pubblicazione su rivista::01a Articolo in rivista
Position Effect Variegation and Viability Are Both Sensitive to Dosage of Constitutive Heterochromatin in Drosophila / M., Berloco; G., Palumbo; Piacentini, Lucia; Pimpinelli, Sergio; Fanti, Laura. - In: G3. - ISSN 2160-1836. - STAMPA. - 4:9(2014), pp. 1709-1716. [10.1534/g3.114.013045]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/627990
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