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Background: Little is known about the incidence and risk factors for serious non-AIDS-defining events. Methods: The incidence of non-AIDS events (malignancies, end-stage renal disease, liver failure, pancreatitis, cardiovascular disease), and AIDS after January 1, 2001, was calculated; Poisson regression was used to investigate factors associated with non-AIDS and AIDS. Results: Among 12,844 patients, 1058 were diagnosed with a non-AIDS event [incidence 1.77 per 100 person-years of follow-up; 95% confidence interval (CI): 1.66 to 1.87]; 462 patients (43.7%) died. The incidence of AIDS (1025 diagnoses; 339 deaths, 33.1%) was 1.72 per 100 person-years of follow-up (1.61 to 1.83). After adjustment, older age [incidence rate ratio (IRR): 1.71 per 10 years older, 95% CI: 1.60 to 1.83], diabetes (IRR: 1.49, 95% CI: 1.22 to 1.82) and hypertension (IRR: 1.63, 95% CI: 1.43 to 1.87) were associated with non-AIDS events. Compared with patients without an event, there was a 4-fold increased risk of death after an AIDS event (relative hazard: 4.14; 95% CI 3.47 to 4.94) and almost a 7-fold increased risk of death after a non-AIDS event (relative hazard: 6.72; 95% CI: 5.61 to 8.05). Conclusions: Non-AIDS events were common in the combination antiretroviral therapy era and associated with considerably mortality. Evidence on the impact of modifying immunodeficiency and lifestyle-related factors on the risk of non-AIDS events in HIV-infected persons is an important but unmet research need.

Serious Fatal and Nonfatal Non-AIDS-Defining Illnesses in Europe / Mocroft, A1; Reiss, P; Gasiorowski, J; Ledergerber, B; Kowalska, J; Chiesi, A; Gatell, J; Rakhmanova, A; Johnson, M; Kirk, O; Lundgren, J; EuroSIDA Study Group., Collaborators (196) Losso M; Elias, C; Vetter, N; Zangerle, R; Karpov, I; Vassilenko, A; Suetnov, O; Clumeck, N; De Wit, S; Poll, B; Colebunders, R; Vandekerckhove, L; Hadziosmanovic, V; Kostov, K; Begovac, J; Machala, L; Rozsypal, H; Sedlacek, D; Gerstoft, J; Kronborg, G; Benfield, T; Larsen, M; Gerstoft, J; Katzenstein, T; Hansen, Ab; Skinhøj, P; Pedersen, C; Zilmer, K; Ristola, M; Katlama, C; Viard, Jp; Girard, Pm; Livrozet, Jm; Vanhems, P; Pradier, C; Dabis, F; Neau, D; Rockstroh, J; Schmidt, R; van Lunzen, J; Degen, O; Stellbrink, Hj; Staszewski, S; Bogner, J; Fätkenheuer, G; Kosmidis, J; Gargalianos, P; Xylomenos, G; Perdios, J; Panos, G; Filandras, A; Karabatsaki, E; Sambatakou, H; Banhegyi, D; Mulcahy, F; Yust, I; Turner, D; Burke, M; Pollack, S; Hassoun, G; Maayan, S; Chiesi, A; Esposito, R; Mazeu, I; Mussini, C; Arici, C; Pristera, R; Mazzotta, F; Gabbuti, A; Vullo, V; Lichtner, M; Chirianni, A; Montesarchio, E; Gargiulo, M; Antonucci, G; Iacomi, F; Narciso, P; Vlassi, C; Zaccarelli, M; Lazzarin, A; Finazzi, R; Galli, M; Ridolfo, A; d'Arminio Monforte, A; Rozentale, B; Chaplinskas, S; Hemmer, R; Staub, T; Reiss, P; Bruun, J; Maeland, A; Ormaasen, V; Knysz, B; Gasiorowski, J; Horban, A; Bakowska, E; Prokopowicz, D; Flisiak, R; Boron-Kaczmarska, A; Pynka, M; Beniowski, M; Mularska, E; Trocha, H; Jablonowska, E; Malolepsza, E; Wojcik, K; Antunes, F; Valadas, E; Mansinho, K; Maltez, F; Duiculescu, D; Rakhmanova, A; Vinogradova, E; Buzunova, S; Jevtovic, D; Mokrá, M; Stanekova, D; Tomazic, J; González-Lahoz, J; Soriano, V; Martin-Carbonero, L; Labarga, P; Moreno, S; Clotet, B; Carlos, A 3rd; Moreno, S; Clotet, B; Jou, A; Paredes, R; Tural, C; Puig, J; Bravo, I; Gatell, Jm; Miró, Jm; Domingo, P; Gutierrez, M; Mateo, G; Sambeat, Ma; Karlsson, A; Persson, Po; Flamholc, L; Ledergerber, B; Weber, R; Francioli, P; Cavassini, M; Hirschel, B; Boffi, E; Furrer, H; Battegay, M; Elzi, L; Kravchenko, E; Chentsova, N; Kutsyna, G; Servitskiy, S; Antoniak, S; Krasnov, M; Barton, S; Johnson, Am; Mercey, D; Phillips, A; Johnson, Ma; Mocroft, A; Murphy, M; Weber, J; Scullard, G; Fisher, M; Leen, C; Clotet, B; Paredes, R; Antunes, F; Clotet, B; Duiculescu, D; Gatell, J; Gazzard, B; Horban, A; Karlsson, A; Katlama, C; Ledergerber, B; D'Arminio Montforte, A; Phillips, A; Rakhmanova, A; Reiss, P; Rockstroh, J; Lundgren, J; Kirk, O; Mocroft, A; Friis-Møller, N; Cozzi-Lepri, A; Bannister, W; Ellefson, M; Borch, A; Podlekareva, D; Kjaer, J; Peters, L; Reekie, J; Kowalska, J. - In: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. - ISSN 1525-4135. - ELETTRONICO. - 55:2(2010), pp. 262-270. [10.1097/qai.0b013e3181e9be6b]

Serious Fatal and Nonfatal Non-AIDS-Defining Illnesses in Europe

Chiesi A;Johnson M;Pedersen C;Schmidt R;Chiesi A;Vullo V;Lichtner M;Iacomi F;d'Arminio Monforte A;Boffi E;
2010

Abstract

Background: Little is known about the incidence and risk factors for serious non-AIDS-defining events. Methods: The incidence of non-AIDS events (malignancies, end-stage renal disease, liver failure, pancreatitis, cardiovascular disease), and AIDS after January 1, 2001, was calculated; Poisson regression was used to investigate factors associated with non-AIDS and AIDS. Results: Among 12,844 patients, 1058 were diagnosed with a non-AIDS event [incidence 1.77 per 100 person-years of follow-up; 95% confidence interval (CI): 1.66 to 1.87]; 462 patients (43.7%) died. The incidence of AIDS (1025 diagnoses; 339 deaths, 33.1%) was 1.72 per 100 person-years of follow-up (1.61 to 1.83). After adjustment, older age [incidence rate ratio (IRR): 1.71 per 10 years older, 95% CI: 1.60 to 1.83], diabetes (IRR: 1.49, 95% CI: 1.22 to 1.82) and hypertension (IRR: 1.63, 95% CI: 1.43 to 1.87) were associated with non-AIDS events. Compared with patients without an event, there was a 4-fold increased risk of death after an AIDS event (relative hazard: 4.14; 95% CI 3.47 to 4.94) and almost a 7-fold increased risk of death after a non-AIDS event (relative hazard: 6.72; 95% CI: 5.61 to 8.05). Conclusions: Non-AIDS events were common in the combination antiretroviral therapy era and associated with considerably mortality. Evidence on the impact of modifying immunodeficiency and lifestyle-related factors on the risk of non-AIDS events in HIV-infected persons is an important but unmet research need.
2010
aids-defining illnesses; cd4; hiv; morbidity; mortality; non-aids-defining illnesses
01 Pubblicazione su rivista::01a Articolo in rivista
Serious Fatal and Nonfatal Non-AIDS-Defining Illnesses in Europe / Mocroft, A1; Reiss, P; Gasiorowski, J; Ledergerber, B; Kowalska, J; Chiesi, A; Gatell, J; Rakhmanova, A; Johnson, M; Kirk, O; Lundgren, J; EuroSIDA Study Group., Collaborators (196) Losso M; Elias, C; Vetter, N; Zangerle, R; Karpov, I; Vassilenko, A; Suetnov, O; Clumeck, N; De Wit, S; Poll, B; Colebunders, R; Vandekerckhove, L; Hadziosmanovic, V; Kostov, K; Begovac, J; Machala, L; Rozsypal, H; Sedlacek, D; Gerstoft, J; Kronborg, G; Benfield, T; Larsen, M; Gerstoft, J; Katzenstein, T; Hansen, Ab; Skinhøj, P; Pedersen, C; Zilmer, K; Ristola, M; Katlama, C; Viard, Jp; Girard, Pm; Livrozet, Jm; Vanhems, P; Pradier, C; Dabis, F; Neau, D; Rockstroh, J; Schmidt, R; van Lunzen, J; Degen, O; Stellbrink, Hj; Staszewski, S; Bogner, J; Fätkenheuer, G; Kosmidis, J; Gargalianos, P; Xylomenos, G; Perdios, J; Panos, G; Filandras, A; Karabatsaki, E; Sambatakou, H; Banhegyi, D; Mulcahy, F; Yust, I; Turner, D; Burke, M; Pollack, S; Hassoun, G; Maayan, S; Chiesi, A; Esposito, R; Mazeu, I; Mussini, C; Arici, C; Pristera, R; Mazzotta, F; Gabbuti, A; Vullo, V; Lichtner, M; Chirianni, A; Montesarchio, E; Gargiulo, M; Antonucci, G; Iacomi, F; Narciso, P; Vlassi, C; Zaccarelli, M; Lazzarin, A; Finazzi, R; Galli, M; Ridolfo, A; d'Arminio Monforte, A; Rozentale, B; Chaplinskas, S; Hemmer, R; Staub, T; Reiss, P; Bruun, J; Maeland, A; Ormaasen, V; Knysz, B; Gasiorowski, J; Horban, A; Bakowska, E; Prokopowicz, D; Flisiak, R; Boron-Kaczmarska, A; Pynka, M; Beniowski, M; Mularska, E; Trocha, H; Jablonowska, E; Malolepsza, E; Wojcik, K; Antunes, F; Valadas, E; Mansinho, K; Maltez, F; Duiculescu, D; Rakhmanova, A; Vinogradova, E; Buzunova, S; Jevtovic, D; Mokrá, M; Stanekova, D; Tomazic, J; González-Lahoz, J; Soriano, V; Martin-Carbonero, L; Labarga, P; Moreno, S; Clotet, B; Carlos, A 3rd; Moreno, S; Clotet, B; Jou, A; Paredes, R; Tural, C; Puig, J; Bravo, I; Gatell, Jm; Miró, Jm; Domingo, P; Gutierrez, M; Mateo, G; Sambeat, Ma; Karlsson, A; Persson, Po; Flamholc, L; Ledergerber, B; Weber, R; Francioli, P; Cavassini, M; Hirschel, B; Boffi, E; Furrer, H; Battegay, M; Elzi, L; Kravchenko, E; Chentsova, N; Kutsyna, G; Servitskiy, S; Antoniak, S; Krasnov, M; Barton, S; Johnson, Am; Mercey, D; Phillips, A; Johnson, Ma; Mocroft, A; Murphy, M; Weber, J; Scullard, G; Fisher, M; Leen, C; Clotet, B; Paredes, R; Antunes, F; Clotet, B; Duiculescu, D; Gatell, J; Gazzard, B; Horban, A; Karlsson, A; Katlama, C; Ledergerber, B; D'Arminio Montforte, A; Phillips, A; Rakhmanova, A; Reiss, P; Rockstroh, J; Lundgren, J; Kirk, O; Mocroft, A; Friis-Møller, N; Cozzi-Lepri, A; Bannister, W; Ellefson, M; Borch, A; Podlekareva, D; Kjaer, J; Peters, L; Reekie, J; Kowalska, J. - In: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. - ISSN 1525-4135. - ELETTRONICO. - 55:2(2010), pp. 262-270. [10.1097/qai.0b013e3181e9be6b]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/139989
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