BACKGROUND: Azathioprine (AZA) and 6-mercaptopurine (6-MP), purine analogues, are the immunosuppressant drugs most frequently used for inducing and maintaining remission in inflammatory bowel disease (IBD). The occurrence of adverse effects is a major drawback in the use of these drugs, and short- and long-term toxicity represent a major limitation to their use. AIM: The present study investigated the prevalence, type and time of onset of AZA-related adverse events, in a cohort of IBD patients in a single referral Centre. PATIENTS AND METHODS: The records of consecutive IBD outpatients, referred to our Institution between 1987-2009, were retrospectively evaluated. RESULTS: We reviewed 2014 patients, in whom AZA was prescribed in 302 of them, 139 (46%) with ulcerative colitis (UC) and 163 (54%) with Crohn’s disease (CD). Side-effects were complained by 98 (32.4%) out of 302 patients, 50 UC and 48 CD, (36% UC vs 29.4% CD, p = 0.26). In 20 (20.4%) patients, 11 UC and 9 CD, side-effects re

Azathioprine treatment in inflammatory bowel disease patients: type and time of onset of side effects / ELEONORA VERONICA, Avallone; Roberta, Pica; Cassieri, Claudio; Zippi, Maddalena; Paolo, Paoluzi; Vernia, Piero. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 1128-3602. - 18:(2014), pp. 165-170.

Azathioprine treatment in inflammatory bowel disease patients: type and time of onset of side effects

CASSIERI, CLAUDIO;ZIPPI, MADDALENA;VERNIA, Piero
2014

Abstract

BACKGROUND: Azathioprine (AZA) and 6-mercaptopurine (6-MP), purine analogues, are the immunosuppressant drugs most frequently used for inducing and maintaining remission in inflammatory bowel disease (IBD). The occurrence of adverse effects is a major drawback in the use of these drugs, and short- and long-term toxicity represent a major limitation to their use. AIM: The present study investigated the prevalence, type and time of onset of AZA-related adverse events, in a cohort of IBD patients in a single referral Centre. PATIENTS AND METHODS: The records of consecutive IBD outpatients, referred to our Institution between 1987-2009, were retrospectively evaluated. RESULTS: We reviewed 2014 patients, in whom AZA was prescribed in 302 of them, 139 (46%) with ulcerative colitis (UC) and 163 (54%) with Crohn’s disease (CD). Side-effects were complained by 98 (32.4%) out of 302 patients, 50 UC and 48 CD, (36% UC vs 29.4% CD, p = 0.26). In 20 (20.4%) patients, 11 UC and 9 CD, side-effects re
2014
Azathioprine; Side-effects; ulcerative colitis; Crohn’s Disease
01 Pubblicazione su rivista::01a Articolo in rivista
Azathioprine treatment in inflammatory bowel disease patients: type and time of onset of side effects / ELEONORA VERONICA, Avallone; Roberta, Pica; Cassieri, Claudio; Zippi, Maddalena; Paolo, Paoluzi; Vernia, Piero. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 1128-3602. - 18:(2014), pp. 165-170.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/549364
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