Low high-density lipoprotein cholesterol (HDL-C) levels are associated with cardiovascular (CV) disease in type 2 diabetes (T2D). Unfortunately available drugs to increase HDL-C have failed to demonstrate a reduction in CV risk. We assessed the effect of improving glycemic control on HDL-C levels. A 6-month intervention resulted in significant improvement in HbA1c but not in HDL-C levels. However, when considering the subgroup of subjects with low levels of HDL-C at baseline, we found a significant and inverse relation between improvement in HbA1c and HDL-C levels. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
The relation between glycemic control and HDL-C in type 2 diabetes: a preliminary step forward? / Barbarossa, Giulia; Renzi, Alessandra; D'Erasmo, Laura; Gallo, Antonio; E., Grieco; Rossetti, Marco; A., Carnovale; M., Santilli; Mandosi, Elisabetta; Coletta, Paola; Pergolini, Daniela; Morano, Susanna; Maranghi, Marianna. - In: DIABETES RESEARCH AND CLINICAL PRACTICE. - ISSN 0168-8227. - STAMPA. - 104:1(2014), pp. E26-E28. [10.1016/j.diabres.2013.12.061]
The relation between glycemic control and HDL-C in type 2 diabetes: a preliminary step forward?
BARBAROSSA, GIULIA;RENZI, ALESSANDRA;D'ERASMO, LAURA;GALLO, ANTONIO;ROSSETTI, MARCO;MANDOSI, ELISABETTA;COLETTA, PAOLA;PERGOLINI, DANIELA;MORANO, Susanna;MARANGHI, MARIANNA
2014
Abstract
Low high-density lipoprotein cholesterol (HDL-C) levels are associated with cardiovascular (CV) disease in type 2 diabetes (T2D). Unfortunately available drugs to increase HDL-C have failed to demonstrate a reduction in CV risk. We assessed the effect of improving glycemic control on HDL-C levels. A 6-month intervention resulted in significant improvement in HbA1c but not in HDL-C levels. However, when considering the subgroup of subjects with low levels of HDL-C at baseline, we found a significant and inverse relation between improvement in HbA1c and HDL-C levels. (C) 2014 Elsevier Ireland Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
