The identification of a series of non-coding RNA (ncRNA) families, with regulatory roles in several biological processes, represents one of the most relevant advances derived from transcriptome analysis. These ncRNAs are actively transcribed from the genome of many organisms. Among them microRNAs (miRNAs) are small regulatory, single-stranded, RNA molecules (19–25 nucleotides in length) that are generated in the nucleus as hairpin primary transcripts. miRNAs processing is carried out initially in the nucleus and later on in the cy-toplasm, where the mature miRNAs molecules, through a limited base-pairing complemen-tarity, destabilize or block the translation of their phylogenetically conserved target tran-scripts [1]. miRNAs exert their function assembled in the RNA-induced silencing complexes (RISCs), where members of Argonaute (Ago) family of proteins provide a unique platform for target recognition and gene silencing. Interestingly, recent evidences also suggest that miRNAs and epig
Microrna pathways as new functional axes in cell fate determination / Fazi, Francesco. - In: ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY. - ISSN 1122-6714. - STAMPA. - 118, Issue 2 SUPPL:(2013), pp. 9-9. (Intervento presentato al convegno 67° Congresso Nazionale SIAI tenutosi a Brescia, Italy nel 20-22 Settembre 2013).
Microrna pathways as new functional axes in cell fate determination
FAZI, Francesco
2013
Abstract
The identification of a series of non-coding RNA (ncRNA) families, with regulatory roles in several biological processes, represents one of the most relevant advances derived from transcriptome analysis. These ncRNAs are actively transcribed from the genome of many organisms. Among them microRNAs (miRNAs) are small regulatory, single-stranded, RNA molecules (19–25 nucleotides in length) that are generated in the nucleus as hairpin primary transcripts. miRNAs processing is carried out initially in the nucleus and later on in the cy-toplasm, where the mature miRNAs molecules, through a limited base-pairing complemen-tarity, destabilize or block the translation of their phylogenetically conserved target tran-scripts [1]. miRNAs exert their function assembled in the RNA-induced silencing complexes (RISCs), where members of Argonaute (Ago) family of proteins provide a unique platform for target recognition and gene silencing. Interestingly, recent evidences also suggest that miRNAs and epigI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
