Tumor initiation and progression are the outcomes of a stepwise accumulation of genetic alterations. Among these, gene amplification and aberrant expression of oncogenic proteins, as well as deletion or inactivation of tumor suppressor genes, represent hallmark steps. Mounting evidence collected over the last few years has identified different populations of non-coding RNAs as major players in tumor suppression in almost all cancer types. Elucidating the diverse molecular mechanisms underlying the roles of non-coding RNAs in tumor progression might provide illuminating insights, potentially able to assist improved diagnosis, better staging and effective treatments of human cancers. Here we focus on several groups of tumor suppressor microRNAs, whose downregulation exerts a profound oncologic impact and might be harnessed for the benefit of cancer patients.

Tumor suppressor microRNAs: A novel non-coding alliance against cancer / Blandino, G; Fazi, Francesco; Donzelli, S; Kedmi, M; Sas Chen, A; Muti, P; Strano, S; Yarden, Y.. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 588:(2014), pp. 2639-2652. [10.1016/j.febslet.2014.03.033]

Tumor suppressor microRNAs: A novel non-coding alliance against cancer.

FAZI, Francesco;
2014

Abstract

Tumor initiation and progression are the outcomes of a stepwise accumulation of genetic alterations. Among these, gene amplification and aberrant expression of oncogenic proteins, as well as deletion or inactivation of tumor suppressor genes, represent hallmark steps. Mounting evidence collected over the last few years has identified different populations of non-coding RNAs as major players in tumor suppression in almost all cancer types. Elucidating the diverse molecular mechanisms underlying the roles of non-coding RNAs in tumor progression might provide illuminating insights, potentially able to assist improved diagnosis, better staging and effective treatments of human cancers. Here we focus on several groups of tumor suppressor microRNAs, whose downregulation exerts a profound oncologic impact and might be harnessed for the benefit of cancer patients.
2014
01 Pubblicazione su rivista::01a Articolo in rivista
Tumor suppressor microRNAs: A novel non-coding alliance against cancer / Blandino, G; Fazi, Francesco; Donzelli, S; Kedmi, M; Sas Chen, A; Muti, P; Strano, S; Yarden, Y.. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 588:(2014), pp. 2639-2652. [10.1016/j.febslet.2014.03.033]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/553095
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 36
  • Scopus 63
  • ???jsp.display-item.citation.isi??? 54
social impact