There is evidence that inflammatory bowel disease is immunologically mediated and that genetic factors play an important aetiological role. The identification of disease susceptibility genes has led to significant progress in our understanding of the pathogenesis of Crohn's disease. Genes linked to Crohn's disease play critical roles in the normal function of the innate immune system, and genes linked to epithelial integrity may play a role in the pathogenesis of inflammatory bowel disease as well. However, the dynamic epidemiology of both Crohn's disease and ulcerative colitis suggests that extrinsic environmental factors acting at the population level may be involved in their pathogenesis. These environmental factors may be responsible for the rising incidence of inflammatory bowel disease

Epidemiology, genes and inflammatory bowel diseases in childhood / M. B., de Mesquita; Civitelli, Fortunata; A., Levine. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 1:40(2008), pp. 3-11.

Epidemiology, genes and inflammatory bowel diseases in childhood

CIVITELLI, FORTUNATA;
2008

Abstract

There is evidence that inflammatory bowel disease is immunologically mediated and that genetic factors play an important aetiological role. The identification of disease susceptibility genes has led to significant progress in our understanding of the pathogenesis of Crohn's disease. Genes linked to Crohn's disease play critical roles in the normal function of the innate immune system, and genes linked to epithelial integrity may play a role in the pathogenesis of inflammatory bowel disease as well. However, the dynamic epidemiology of both Crohn's disease and ulcerative colitis suggests that extrinsic environmental factors acting at the population level may be involved in their pathogenesis. These environmental factors may be responsible for the rising incidence of inflammatory bowel disease
2008
01 Pubblicazione su rivista::01a Articolo in rivista
Epidemiology, genes and inflammatory bowel diseases in childhood / M. B., de Mesquita; Civitelli, Fortunata; A., Levine. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 1:40(2008), pp. 3-11.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/542496
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