Recent advances in brain energy metabolism support the notion that glycogen in astrocytes is necessary for the clearance of neuronally-released K + from the extracellular space. However, how the multiple metabolic pathways involved in K+-induced increase in glycogen turnover are regulated is only partly understood. Here we summarize the current knowledge about the mechanisms that control glycogen metabolism during enhanced K + uptake. We also describe the action of the ubiquitous Na +/K+ ATPase for both ion transport and intracellular signaling cascades, and emphasize its importance in understanding the complex relation between glycogenolysis and K+ uptake. © 2013 Elsevier B.V. All rights reserved.
Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes / Mauro, Dinuzzo; Silvia, Mangia; Maraviglia, Bruno; Giove, Federico. - In: NEUROCHEMISTRY INTERNATIONAL. - ISSN 0197-0186. - STAMPA. - 63:5(2013), pp. 458-464. [10.1016/j.neuint.2013.08.004]
Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes
MARAVIGLIA, Bruno;GIOVE, FEDERICO
2013
Abstract
Recent advances in brain energy metabolism support the notion that glycogen in astrocytes is necessary for the clearance of neuronally-released K + from the extracellular space. However, how the multiple metabolic pathways involved in K+-induced increase in glycogen turnover are regulated is only partly understood. Here we summarize the current knowledge about the mechanisms that control glycogen metabolism during enhanced K + uptake. We also describe the action of the ubiquitous Na +/K+ ATPase for both ion transport and intracellular signaling cascades, and emphasize its importance in understanding the complex relation between glycogenolysis and K+ uptake. © 2013 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.