Background: We investigated a possible association between pharyngeal/tonsillar carcinoma and mixed carcinogen exposures in an asphalt roll company in Italy that used asbestos until 1979, when a new factory was built using a different production process. Methods: We evaluated all workers involved in the entire production history of the company, divided into two subcohorts based on exposure status (workers in the original factory, 1964-1979, and those who worked only in the new factory, 1980-1997). We ascertained the vital status of the study population in February 2001. Results: Among the subset of workers in the earlier subcohort, there were five deaths from pharyngeal/tonsillar carcinoma for a standardized mortality ratio of 21 (95% confidence interval = 8.8-51). No cases were recorded among workers hired after 1979. Conclusion: The increased standardized mortality ratio for this relatively rare cancer among workers exposed before 1979 may have been due to carcinogenic exposures at the plant. © 2012 by Lippincott William & Wilkins.

Carcinoma of the pharynx and tonsils in an occupational cohort of asphalt workers / Francesca, Zanardi; Renata, Salvarani; Robin M. T., Cooke; Pirastu, Roberta; Michela, Baccini; David, Christiani; Stefania, Curti; Alessandro, Risi; Anna, Barbieri; Giuseppe, Barbieri; Stefano, Mattioli; Francesco Saverio, Violante. - In: EPIDEMIOLOGY. - ISSN 1044-3983. - STAMPA. - 24:1(2013), pp. 100-103. [10.1097/ede.0b013e318276cc95]

Carcinoma of the pharynx and tonsils in an occupational cohort of asphalt workers

PIRASTU, Roberta;
2013

Abstract

Background: We investigated a possible association between pharyngeal/tonsillar carcinoma and mixed carcinogen exposures in an asphalt roll company in Italy that used asbestos until 1979, when a new factory was built using a different production process. Methods: We evaluated all workers involved in the entire production history of the company, divided into two subcohorts based on exposure status (workers in the original factory, 1964-1979, and those who worked only in the new factory, 1980-1997). We ascertained the vital status of the study population in February 2001. Results: Among the subset of workers in the earlier subcohort, there were five deaths from pharyngeal/tonsillar carcinoma for a standardized mortality ratio of 21 (95% confidence interval = 8.8-51). No cases were recorded among workers hired after 1979. Conclusion: The increased standardized mortality ratio for this relatively rare cancer among workers exposed before 1979 may have been due to carcinogenic exposures at the plant. © 2012 by Lippincott William & Wilkins.
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Carcinoma of the pharynx and tonsils in an occupational cohort of asphalt workers / Francesca, Zanardi; Renata, Salvarani; Robin M. T., Cooke; Pirastu, Roberta; Michela, Baccini; David, Christiani; Stefania, Curti; Alessandro, Risi; Anna, Barbieri; Giuseppe, Barbieri; Stefano, Mattioli; Francesco Saverio, Violante. - In: EPIDEMIOLOGY. - ISSN 1044-3983. - STAMPA. - 24:1(2013), pp. 100-103. [10.1097/ede.0b013e318276cc95]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/517658
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