Matrix metalloproteinases (MMPs) are endopeptidases involved in many physiological and physical processes. They synthesize and secrete numerous cytokines, growth factors, hormone receptors and cell adhesion molecules The use of metalloproteinase inhibitors has been surmised in the treatment of important diseases such as cancer, neurodegenerative and cardiovascular diseases and various types of inflammatory diseases. With regard to the eyes, metalloproteinases and their inhibitors are implicated in the pathogenesis of diseases such as diabetic retinopathy, primary open-angle glaucoma, pseudoexfoliative glaucoma, corneal neovascularization and ulcerations (viral and bacterial), superior limbic keratoconjunctivitis, and climatic droplet keratopathy (CDK); they are secreted by the cells of the trabecular meshwork and their secretion increases after trabeculectomy surgery. They also take part in causing damage in the case of dry eye disease, pterygium, choroidal neovascularization (CNV) and age-related macular degeneration (AMD).

METALLOPROTEINASES AND EYE DISEASES / Pescosolido, Nicola; R., Giannotti; G., Buomprisco. - In: BIOMEDICINE & AGING PATHOLOGY. - ISSN 2210-5220. - STAMPA. - 3:3(2013), pp. 97-105. [10.1016/j.biomag.2013.06.003]

METALLOPROTEINASES AND EYE DISEASES

PESCOSOLIDO, Nicola;
2013

Abstract

Matrix metalloproteinases (MMPs) are endopeptidases involved in many physiological and physical processes. They synthesize and secrete numerous cytokines, growth factors, hormone receptors and cell adhesion molecules The use of metalloproteinase inhibitors has been surmised in the treatment of important diseases such as cancer, neurodegenerative and cardiovascular diseases and various types of inflammatory diseases. With regard to the eyes, metalloproteinases and their inhibitors are implicated in the pathogenesis of diseases such as diabetic retinopathy, primary open-angle glaucoma, pseudoexfoliative glaucoma, corneal neovascularization and ulcerations (viral and bacterial), superior limbic keratoconjunctivitis, and climatic droplet keratopathy (CDK); they are secreted by the cells of the trabecular meshwork and their secretion increases after trabeculectomy surgery. They also take part in causing damage in the case of dry eye disease, pterygium, choroidal neovascularization (CNV) and age-related macular degeneration (AMD).
2013
Metalloproteinases; Timps; Diabetic retinopathy; Corneal neovascularization; Trabeculectomy; Superior limbic keratoconjunctivitis; Dry eye disease; age-related macular degeneration
01 Pubblicazione su rivista::01a Articolo in rivista
METALLOPROTEINASES AND EYE DISEASES / Pescosolido, Nicola; R., Giannotti; G., Buomprisco. - In: BIOMEDICINE & AGING PATHOLOGY. - ISSN 2210-5220. - STAMPA. - 3:3(2013), pp. 97-105. [10.1016/j.biomag.2013.06.003]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/517376
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 9
  • ???jsp.display-item.citation.isi??? ND
social impact