Tourette syndrome is a neurodevelopmental disorder characterized by multiple tics and is often associated with comorbid behavioral problems. Research with generic instruments in child populations showed that comorbid disorders can have a greater impact on health-related quality of life than tic severity. This study investigated the usefulness of a newly developed disease-specific instrument, the Gilles de la Tourette Syndrome-Quality of Life Scale for Children and Adolescents (GTS-QOL-C&A), in assessing health-related quality of life in young patients with Tourette syndrome with and without behavioral comorbidity. We recruited 75 patients with Tourette syndrome (60 males; age 12.4 ± 3.2 years). All participants were evaluated by a neuropsychiatrist and completed a standardized psychometric battery, including the GTS-QOL-C&A, Child Depression Inventory, and Multidimensional Anxiety Scale for Children. Forty-two patients (56%) fulfilled diagnostic criteria for at least one comorbidity: obsessive-compulsive disorder (n = 25 patients [33.3%]); attention deficit/hyperactivity disorder (n = 6 patients [8%]); both (n = 11 patients [14.7%]). The GTS-QOL-C&A demonstrated usefulness in differentiating "pure" Tourette syndrome from Tourette syndrome "plus" behavioral problems with regard to health-related quality of life scores for the obsessive-compulsive subscale. In addition to focusing on core tic symptoms, the GTS-QOL-C&A showed sensitivity to the impact of behavioral comorbidities on health-related quality of life and can usefully complement existing nonspecific instruments. © 2013 Elsevier Inc. All rights reserved.

Disease-specific quality of life in young patients with Tourette syndrome / Andrea E., Cavanna; Chiara, Luoni; Claudia, Selvini; Rosanna, Blangiardo; Clare M., Eddy; Silvestri, PAOLA ROSARIA; Paola V., Cali; Emanuela, Gagliardi; Umberto, Balottin; Cardona, Francesco Carmelo Giovanni; Renata, Rizzo; Cristiano, Termine. - In: PEDIATRIC NEUROLOGY. - ISSN 0887-8994. - 48:2(2013), pp. 111-114. [10.1016/j.pediatrneurol.2012.10.006]

Disease-specific quality of life in young patients with Tourette syndrome

SILVESTRI, PAOLA ROSARIA;CARDONA, Francesco Carmelo Giovanni;
2013

Abstract

Tourette syndrome is a neurodevelopmental disorder characterized by multiple tics and is often associated with comorbid behavioral problems. Research with generic instruments in child populations showed that comorbid disorders can have a greater impact on health-related quality of life than tic severity. This study investigated the usefulness of a newly developed disease-specific instrument, the Gilles de la Tourette Syndrome-Quality of Life Scale for Children and Adolescents (GTS-QOL-C&A), in assessing health-related quality of life in young patients with Tourette syndrome with and without behavioral comorbidity. We recruited 75 patients with Tourette syndrome (60 males; age 12.4 ± 3.2 years). All participants were evaluated by a neuropsychiatrist and completed a standardized psychometric battery, including the GTS-QOL-C&A, Child Depression Inventory, and Multidimensional Anxiety Scale for Children. Forty-two patients (56%) fulfilled diagnostic criteria for at least one comorbidity: obsessive-compulsive disorder (n = 25 patients [33.3%]); attention deficit/hyperactivity disorder (n = 6 patients [8%]); both (n = 11 patients [14.7%]). The GTS-QOL-C&A demonstrated usefulness in differentiating "pure" Tourette syndrome from Tourette syndrome "plus" behavioral problems with regard to health-related quality of life scores for the obsessive-compulsive subscale. In addition to focusing on core tic symptoms, the GTS-QOL-C&A showed sensitivity to the impact of behavioral comorbidities on health-related quality of life and can usefully complement existing nonspecific instruments. © 2013 Elsevier Inc. All rights reserved.
2013
01 Pubblicazione su rivista::01a Articolo in rivista
Disease-specific quality of life in young patients with Tourette syndrome / Andrea E., Cavanna; Chiara, Luoni; Claudia, Selvini; Rosanna, Blangiardo; Clare M., Eddy; Silvestri, PAOLA ROSARIA; Paola V., Cali; Emanuela, Gagliardi; Umberto, Balottin; Cardona, Francesco Carmelo Giovanni; Renata, Rizzo; Cristiano, Termine. - In: PEDIATRIC NEUROLOGY. - ISSN 0887-8994. - 48:2(2013), pp. 111-114. [10.1016/j.pediatrneurol.2012.10.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/508152
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