Objective Isolated Systolic Hypertension (ISH) is a known risk factor for cognitive impairment, but the time of onset of neurocognitive changes relative to the onset of ISH has yet to be established. The purpose of this study was to investigate the relationship between systolic BP values and neurocognitive function in the early stages of ISH. Methods Twenty elderly patients with recently (<2 years) diagnosed ISH and 10 elderly normotensive controls underwent Ambulatory Blood Pressure Monitoring (ABPM) and neurocognitive assessment, performed using the Mini Mental State Examination (MMSE), and the recording of ERPs with an odd ball acoustic paradigm. Results There were no significant differences in MMSE scores or in the P300 latency between ISH patients and controls. The N2 latency was significantly higher in ISH patients vs. controls (p < 0.0001), and showed a significant association with both clinical and ambulatory systolic BP and pulse pressure values in the overall study population. Conclusions These findings suggest the existence of early subclinical alterations in neurocognitive function in early ISH, detectable through ERPs.

Event related brain potentials in elderly patients with recently disgnosed isolated systolic hypertension / Cicconetti, Paolo; Ciotti, V; Tafaro, Laura; Ettorre, Evaristo; Chiarotti, F; Priami, C; Cacciafesta, Mauro; Marigliano, Vincenzo. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - STAMPA. - 118:4(2007), pp. 824-832. [10.1016/j.clinph.2006.11.001]

Event related brain potentials in elderly patients with recently disgnosed isolated systolic hypertension

CICCONETTI, Paolo;TAFARO, LAURA;ETTORRE, Evaristo;CACCIAFESTA, Mauro;MARIGLIANO, Vincenzo
2007

Abstract

Objective Isolated Systolic Hypertension (ISH) is a known risk factor for cognitive impairment, but the time of onset of neurocognitive changes relative to the onset of ISH has yet to be established. The purpose of this study was to investigate the relationship between systolic BP values and neurocognitive function in the early stages of ISH. Methods Twenty elderly patients with recently (<2 years) diagnosed ISH and 10 elderly normotensive controls underwent Ambulatory Blood Pressure Monitoring (ABPM) and neurocognitive assessment, performed using the Mini Mental State Examination (MMSE), and the recording of ERPs with an odd ball acoustic paradigm. Results There were no significant differences in MMSE scores or in the P300 latency between ISH patients and controls. The N2 latency was significantly higher in ISH patients vs. controls (p < 0.0001), and showed a significant association with both clinical and ambulatory systolic BP and pulse pressure values in the overall study population. Conclusions These findings suggest the existence of early subclinical alterations in neurocognitive function in early ISH, detectable through ERPs.
2007
01 Pubblicazione su rivista::01a Articolo in rivista
Event related brain potentials in elderly patients with recently disgnosed isolated systolic hypertension / Cicconetti, Paolo; Ciotti, V; Tafaro, Laura; Ettorre, Evaristo; Chiarotti, F; Priami, C; Cacciafesta, Mauro; Marigliano, Vincenzo. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - STAMPA. - 118:4(2007), pp. 824-832. [10.1016/j.clinph.2006.11.001]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/238000
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