Objectives Attention-deficit hyperactivity disorder (ADHD) is a highly heritable, common developmental disorder. Although a few confirmed associations have emerged from candidate gene studies, these have shown the same limitations that have become evident in the study of other complex diseases, often with inconsistent and nonreplicated results across different studies. Methods In this report, 27 ADHD candidate genes were explored in greater depth using high-density tag single nucleotide polymorphism (SNP) genotyping. Association with 557 SNPs was tested using the transmission disequilibrium test in 270 nuclear pedigrees selected from an ongoing ADHD genetic study that includes all disease subtypes. Results SNPs in seven genes including SLC1A3, SLC6A3, HTR4, ADRA1A, HTR2A, SNAP25, and COMT showed a nominal level of association with ADHD (P values 0.05), but none remained significant after a stringent correction for the total number of tests performed. Conclusion The strongest signal emerged from SNPs in the promoter region (rs3808585) and in an intron (rs17426222, rs4732682, rs573514) of ADRA1A, all located within the same haplotype block. Some of the SNPs inHTR2A and COMT have already been reported by others, whereas other SNPs will need confirmation in independent samples. © 2009 Wolters Kluwer Health | Lippincott Williams &Wilkins.

Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: Suggestive association signals in ADRA1A / Josephine, Elia; Mario, Capasso; Zafar, Zaheer; Francesca, Lantieri; Paul, Ambrosini; Wade, Berrettini; Devoto, Marcella; Hakon, Hakonarson. - In: PSYCHIATRIC GENETICS. - ISSN 0955-8829. - 19:3(2009), pp. 134-141. [10.1097/ypg.0b013e32832a5043]

Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: Suggestive association signals in ADRA1A

DEVOTO, MARCELLA;
2009

Abstract

Objectives Attention-deficit hyperactivity disorder (ADHD) is a highly heritable, common developmental disorder. Although a few confirmed associations have emerged from candidate gene studies, these have shown the same limitations that have become evident in the study of other complex diseases, often with inconsistent and nonreplicated results across different studies. Methods In this report, 27 ADHD candidate genes were explored in greater depth using high-density tag single nucleotide polymorphism (SNP) genotyping. Association with 557 SNPs was tested using the transmission disequilibrium test in 270 nuclear pedigrees selected from an ongoing ADHD genetic study that includes all disease subtypes. Results SNPs in seven genes including SLC1A3, SLC6A3, HTR4, ADRA1A, HTR2A, SNAP25, and COMT showed a nominal level of association with ADHD (P values 0.05), but none remained significant after a stringent correction for the total number of tests performed. Conclusion The strongest signal emerged from SNPs in the promoter region (rs3808585) and in an intron (rs17426222, rs4732682, rs573514) of ADRA1A, all located within the same haplotype block. Some of the SNPs inHTR2A and COMT have already been reported by others, whereas other SNPs will need confirmation in independent samples. © 2009 Wolters Kluwer Health | Lippincott Williams &Wilkins.
2009
association study; attention-deficit hyperactivity disorder; candidate genes; linkage disequilibrium
01 Pubblicazione su rivista::01a Articolo in rivista
Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: Suggestive association signals in ADRA1A / Josephine, Elia; Mario, Capasso; Zafar, Zaheer; Francesca, Lantieri; Paul, Ambrosini; Wade, Berrettini; Devoto, Marcella; Hakon, Hakonarson. - In: PSYCHIATRIC GENETICS. - ISSN 0955-8829. - 19:3(2009), pp. 134-141. [10.1097/ypg.0b013e32832a5043]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/50252
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