The Na,K-ATPase activity of erythrocyte membranes is markedly increased in normal-renin essential hypertensives. A temporal shift of the chronobiology of the erythrocyte-membrane-bound Na,K-ATPase in these patients is described. The disorder causes a loss of synchronism between the circadian rhythms of aldosterone and Na,K-ATPase. Such uncoupling phenomenon may explain the inversion of the day/night sodium excretion ratio and other disturbances of sodium metabolism found in essential hypertensives.
Chronobiological evidence for an uncoupling of the Na,K-ATPase to aldosterone in normal renin hypertension / Cugini, P; Lucia, P; Letizia, C; Murano, G; Scavo, D; Giganti, G; Calogero, A; Verna, Roberto. - In: ENZYME. - ISSN 0013-9432. - STAMPA. - 41:41(1989), pp. 159-167.
Chronobiological evidence for an uncoupling of the Na,K-ATPase to aldosterone in normal renin hypertension.
Lucia P;Calogero A;VERNA, Roberto
1989
Abstract
The Na,K-ATPase activity of erythrocyte membranes is markedly increased in normal-renin essential hypertensives. A temporal shift of the chronobiology of the erythrocyte-membrane-bound Na,K-ATPase in these patients is described. The disorder causes a loss of synchronism between the circadian rhythms of aldosterone and Na,K-ATPase. Such uncoupling phenomenon may explain the inversion of the day/night sodium excretion ratio and other disturbances of sodium metabolism found in essential hypertensives.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
