BACKGROUND:: The aim of this pilot study was to verify the role of olfactory test and volumetric magnetic resonance imaging measure of hippocampus to predict conversion from mild cognitive impairment to Alzheimer disease (AD). MATERIALS AND METHODS:: Eighteen patients with amnesic mild cognitive impairment, broadly defined, were followed at 12 months. Hypothesized baseline predictors for follow-up conversion to AD were olfactory deficit and hippocampal volumes loss. RESULTS:: In the 1-year follow-up, 5 patients converted to AD. The 2 clinical predictors olfactory test and hippocampal volume loss showed the same sensitivity of 92.3% but the olfactory test showed a higher specificity than the hippocampal volume loss (75% vs. 60%). CONCLUSIONS:: Our findings suggest the potential utility of olfactory test and hippocampal volume loss for early detection of AD. Copyright © 2013 by Lippincott Williams & Wilkins.
Olfactory deficit and hippocampal volume loss for early diagnosis of Alzheimer disease: A pilot study / Marigliano, Vincenzo; Gualdi, Gianfranco; Servello, ADRIANA DEBORA; Benedetta, Marigliano; Luigi Della, Volpe; Alessandra, Fioretti; Martina, Pagliarella; Marco, Valenti; Francesco, Masedu; DI BIASI, Claudio; Ettorre, Evaristo; Fusetti, Marco. - In: ALZHEIMER DISEASE & ASSOCIATED DISORDERS. - ISSN 0893-0341. - ELETTRONICO. - 28:2(2014), pp. 194-197. [10.1097/wad.0b013e31827bdb9f]
Olfactory deficit and hippocampal volume loss for early diagnosis of Alzheimer disease: A pilot study
MARIGLIANO, Vincenzo;GUALDI, GIANFRANCO;SERVELLO, ADRIANA DEBORA;DI BIASI, Claudio;ETTORRE, Evaristo;FUSETTI, Marco
2014
Abstract
BACKGROUND:: The aim of this pilot study was to verify the role of olfactory test and volumetric magnetic resonance imaging measure of hippocampus to predict conversion from mild cognitive impairment to Alzheimer disease (AD). MATERIALS AND METHODS:: Eighteen patients with amnesic mild cognitive impairment, broadly defined, were followed at 12 months. Hypothesized baseline predictors for follow-up conversion to AD were olfactory deficit and hippocampal volumes loss. RESULTS:: In the 1-year follow-up, 5 patients converted to AD. The 2 clinical predictors olfactory test and hippocampal volume loss showed the same sensitivity of 92.3% but the olfactory test showed a higher specificity than the hippocampal volume loss (75% vs. 60%). CONCLUSIONS:: Our findings suggest the potential utility of olfactory test and hippocampal volume loss for early detection of AD. Copyright © 2013 by Lippincott Williams & Wilkins.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
