A direct semipreparative HPLC enantioseparation of two chiral thiazolidinone derivatives having cyclooxygenase-2 inhibition activity was performed on the Chiralpak IA chiral stationary phase. Semipreparative amounts of enantiopure forms were collected using acetonitrile-ethanol-trifluoroacetic acid mixtures as mobile phase. The absolute configuration of both compounds was unequivocally established by single-crystal X-ray diffraction method and correlated to the chiroptical properties of isolated enantiomers. Chirality 22:56-62, 2010. (C) 2009 Wiley-Liss, Inc.

Semipreparative HPLC Enantioseparation, Chiroptical Properties, and Absolute Configuration of Two Novel Cyclooxygenase-2 Inhibitors / Roberto, Cirilli; Stefano, Fiore; Francesco La, Torre; Elias, Maccioni; Secci, Daniela; Maria Luisa, Sanna; Cristina, Faggi. - In: CHIRALITY. - ISSN 0899-0042. - 22:1(2010), pp. 56-62. [10.1002/chir.20705]

Semipreparative HPLC Enantioseparation, Chiroptical Properties, and Absolute Configuration of Two Novel Cyclooxygenase-2 Inhibitors

SECCI, DANIELA;
2010

Abstract

A direct semipreparative HPLC enantioseparation of two chiral thiazolidinone derivatives having cyclooxygenase-2 inhibition activity was performed on the Chiralpak IA chiral stationary phase. Semipreparative amounts of enantiopure forms were collected using acetonitrile-ethanol-trifluoroacetic acid mixtures as mobile phase. The absolute configuration of both compounds was unequivocally established by single-crystal X-ray diffraction method and correlated to the chiroptical properties of isolated enantiomers. Chirality 22:56-62, 2010. (C) 2009 Wiley-Liss, Inc.
2010
absolute configuration; anti-inflammatory agents; chiral stationary phase; chiralpak ia; chiroptical properties; cox-2-inhibitors; hplc; sulfonamide derivatives; thiazolidinone derivatives
01 Pubblicazione su rivista::01a Articolo in rivista
Semipreparative HPLC Enantioseparation, Chiroptical Properties, and Absolute Configuration of Two Novel Cyclooxygenase-2 Inhibitors / Roberto, Cirilli; Stefano, Fiore; Francesco La, Torre; Elias, Maccioni; Secci, Daniela; Maria Luisa, Sanna; Cristina, Faggi. - In: CHIRALITY. - ISSN 0899-0042. - 22:1(2010), pp. 56-62. [10.1002/chir.20705]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/48936
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact