Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not only at elucidating their nature and unique properties but also developing cell-based therapies for a diverse range of diseases. More than three decades have passed since the original formulation of the concept, revolutionary at the time, that multiple connective tissues could emanate from a common progenitor or stem cell retained in the postnatal bone marrow. Despite the many important advances made since that time, substantial ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs. These uncertainties have a major impact on their envisioned therapeutic use. © 2013 Nature America, Inc. All rights reserved.

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine / Bianco, Paolo; Xu, Cao; Paul S., Frenette; Jeremy J., Mao; Pamela G., Robey; Paul J., Simmons; Cun Yu, Wang. - In: NATURE MEDICINE. - ISSN 1078-8956. - STAMPA. - 19:1(2013), pp. 35-42. [10.1038/nm.3028]

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine

BIANCO, Paolo;
2013

Abstract

Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not only at elucidating their nature and unique properties but also developing cell-based therapies for a diverse range of diseases. More than three decades have passed since the original formulation of the concept, revolutionary at the time, that multiple connective tissues could emanate from a common progenitor or stem cell retained in the postnatal bone marrow. Despite the many important advances made since that time, substantial ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs. These uncertainties have a major impact on their envisioned therapeutic use. © 2013 Nature America, Inc. All rights reserved.
2013
01 Pubblicazione su rivista::01a Articolo in rivista
The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine / Bianco, Paolo; Xu, Cao; Paul S., Frenette; Jeremy J., Mao; Pamela G., Robey; Paul J., Simmons; Cun Yu, Wang. - In: NATURE MEDICINE. - ISSN 1078-8956. - STAMPA. - 19:1(2013), pp. 35-42. [10.1038/nm.3028]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/488070
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