A number of recessive autosomal genes cause male infertility. Male mice homozygous for the blind-sterile (bs/bs) and quaking-sterile (qk/qk) gene mutations are sterile, because they either do not produce any spermatozoa or produce only a few abnormal spermatozoa. Mice lacking the cyclic AMP responsive-element modulator gene are sterile due to failure of spermiogenesis. All these mice, however, are able to produce fertile offspring when their spermatozoa or round spermatids are injected into oocytes of normal females. This implies that genetic and epigenetic elements necessary for syngamy and embryonic development are established in round spermatids and spermatozoa of these animals, even though their spermatogenic cells are destined to die (bs/bs and qk/qk) or are programmed to undergo apoptosis (cyclic AMP responsive-element modulator-null) without becoming functional spermatozoa.

Production of fertile offspring from genetically infertile male mice / R., Yanagimachi; T., Wakayama; H., Kishikawa; G. M., Fimia; Monaco, Lucia; P., Sassone Corsi. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - STAMPA. - 101:6(2004), pp. 1691-1695. [10.1073/pnas.0307832100]

Production of fertile offspring from genetically infertile male mice

MONACO, Lucia;Fimia, Gian Maria
2004

Abstract

A number of recessive autosomal genes cause male infertility. Male mice homozygous for the blind-sterile (bs/bs) and quaking-sterile (qk/qk) gene mutations are sterile, because they either do not produce any spermatozoa or produce only a few abnormal spermatozoa. Mice lacking the cyclic AMP responsive-element modulator gene are sterile due to failure of spermiogenesis. All these mice, however, are able to produce fertile offspring when their spermatozoa or round spermatids are injected into oocytes of normal females. This implies that genetic and epigenetic elements necessary for syngamy and embryonic development are established in round spermatids and spermatozoa of these animals, even though their spermatogenic cells are destined to die (bs/bs and qk/qk) or are programmed to undergo apoptosis (cyclic AMP responsive-element modulator-null) without becoming functional spermatozoa.
2004
01 Pubblicazione su rivista::01a Articolo in rivista
Production of fertile offspring from genetically infertile male mice / R., Yanagimachi; T., Wakayama; H., Kishikawa; G. M., Fimia; Monaco, Lucia; P., Sassone Corsi. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - STAMPA. - 101:6(2004), pp. 1691-1695. [10.1073/pnas.0307832100]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/48589
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