Visceral leishmaniosis (VL) has emerged as an important opportunistic parasitosis associated with human immunodeficiency virus (HIV) infection. The aim of this paper is to report the first case of Leishmania/HIV coinfection in a patient from Nis (Southeastern Serbia). Microscopical examination of Giemsa-stained bone marrow (BM) smears show the presence of Leishmania spp. amastigotes based on their morphological characteristics. In spite of the parasitological finding, the serological test applied gave negative results. Molecular analyses confirmed the infection and allowed us to identify the leishmania species as Leishmania infantum (100% identity). VL/HIV coinfection has important clinical, diagnostic and epidemiological implications. In fact, the failure of serological tests is expected in this condition, and the application of molecular diagnostics to the blood may offer, apart from an easy and non-invasive diagnostic opportunity, the possibility of warning about the risk of possible nosocomial infections.

FIRST CASE OF VISCERAL LEISHMANIOSIS/HIV COINFECTION IN NIS - SOUTHEASTERN SERBIA / G., Marjanovic; Natasa Miladinovic, Tasic; Gabrielli, Simona; Suzana, Otasevic; Lidija Popovic, Dragonjic; Branislava, Kocic; Valentina Arsić, Arsenijevic; Ljiljana, Tadic; Cancrini, Gabriella. - In: ARCHIVES OF BIOLOGICAL SCIENCES. - ISSN 0354-4664. - STAMPA. - 64:4(2012), pp. 1271-1276. [10.2298/abs1204271m]

FIRST CASE OF VISCERAL LEISHMANIOSIS/HIV COINFECTION IN NIS - SOUTHEASTERN SERBIA

GABRIELLI, SIMONA;CANCRINI, Gabriella
2012

Abstract

Visceral leishmaniosis (VL) has emerged as an important opportunistic parasitosis associated with human immunodeficiency virus (HIV) infection. The aim of this paper is to report the first case of Leishmania/HIV coinfection in a patient from Nis (Southeastern Serbia). Microscopical examination of Giemsa-stained bone marrow (BM) smears show the presence of Leishmania spp. amastigotes based on their morphological characteristics. In spite of the parasitological finding, the serological test applied gave negative results. Molecular analyses confirmed the infection and allowed us to identify the leishmania species as Leishmania infantum (100% identity). VL/HIV coinfection has important clinical, diagnostic and epidemiological implications. In fact, the failure of serological tests is expected in this condition, and the application of molecular diagnostics to the blood may offer, apart from an easy and non-invasive diagnostic opportunity, the possibility of warning about the risk of possible nosocomial infections.
2012
hiv co-infection; visceral leishmaniosis; molecular diagnosis
01 Pubblicazione su rivista::01a Articolo in rivista
FIRST CASE OF VISCERAL LEISHMANIOSIS/HIV COINFECTION IN NIS - SOUTHEASTERN SERBIA / G., Marjanovic; Natasa Miladinovic, Tasic; Gabrielli, Simona; Suzana, Otasevic; Lidija Popovic, Dragonjic; Branislava, Kocic; Valentina Arsić, Arsenijevic; Ljiljana, Tadic; Cancrini, Gabriella. - In: ARCHIVES OF BIOLOGICAL SCIENCES. - ISSN 0354-4664. - STAMPA. - 64:4(2012), pp. 1271-1276. [10.2298/abs1204271m]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/483987
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