Remarks on the behaviour of certain enzymurias in subjects treated with pipemidic acid [CONSIDERAZIONI SUL COMPORTAMENTO DI ALCUNE ENZIMURIE IN SOGGETTI TRATTATI CON ACIDO PIPEMIDICO]

Three groups of subjects (I with infections of the lower urinary tract; II with chronic pyelonephritis; III healthy controls) were treated with pipemidic acid for 10 consecutive days and the behaviour of their urinary NAG and AAP was studied. It was discovered that the healthy group and the patients with infections of the lower urinary tract showed no significant variations in the urinary activity of the two enzymes following the administration of pipemidic acid. However, there was a distinct reduction in both enzymes in patients with chronic pyelonephritis who presented demonstrable bacterial sensitivity to the drug. Apart from the fact that it produces no nephrotoxic effects at least in the doses used and for the treatment period adopted, the drug is considered to reduce renal inflammation that is beneficial to individuals with chronic interstitial nephropathy.