Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are novel biomarkers for acute heart failure (AHF). Like other AFH biomarkers, the performance of these tests are affected by the presence of clinical variables such as renal failure and obesity. In a substudy of the Biomarkers from Acute Heart Failure Study, we show that diabetes did not influence the performance of these markers with regards to AHF diagnosis or 90-day all cause death. However, in patients without AHF, increased MR-proADM alone was associated with the presence of diabetes. © 2012 Informa UK, Ltd.
The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea / Alan H. b., Wu; Jeffrey, Tabas; Johnathan, Stein; Mihael, Potocki; Christian, Mueller; Mccord, James; Richards, Mark; Hartmann, Oliver; Richard, Nowak; W., Frank Peacock; Piotr, Ponikowski; Moeckel, Martin; Hogan, Christopher; Gerasimos S., Filippatos; DI SOMMA, Salvatore; Anand, Inder; Ng, Leong; Sean Xavier, Neath; Robert, Christenson; Nils G., Morgenthaler; Stefan D., Anker; Alan S., Maisel. - In: BIOMARKERS. - ISSN 1354-750X. - STAMPA. - 17:6(2012), pp. 490-497. [10.3109/1354750x.2012.687014]
The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea
DI SOMMA, Salvatore;
2012
Abstract
Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are novel biomarkers for acute heart failure (AHF). Like other AFH biomarkers, the performance of these tests are affected by the presence of clinical variables such as renal failure and obesity. In a substudy of the Biomarkers from Acute Heart Failure Study, we show that diabetes did not influence the performance of these markers with regards to AHF diagnosis or 90-day all cause death. However, in patients without AHF, increased MR-proADM alone was associated with the presence of diabetes. © 2012 Informa UK, Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.