Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.

INHIBITORS OF CAMP PHOSPHODIESTERASE IN MEDICINAL-PLANTS .17. INHIBITION OF ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE PHOSPHODIESTERASE BY FLAVONOIDS FROM LICORICE ROOTS AND 4-ARYLCOUMARINS / A., Kusano; T., Nikaido; T., Kuge; T., Ohmoto; G., Dellemonache; Botta, Bruno; M., Botta; T., Saitoh. - In: CHEMICAL & PHARMACEUTICAL BULLETIN. - ISSN 0009-2363. - 39:(1991), pp. 930-933.

INHIBITORS OF CAMP PHOSPHODIESTERASE IN MEDICINAL-PLANTS .17. INHIBITION OF ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE PHOSPHODIESTERASE BY FLAVONOIDS FROM LICORICE ROOTS AND 4-ARYLCOUMARINS

BOTTA, Bruno;
1991

Abstract

Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.
1991
3-arylcoumarin; 4-arylcoumarin; camp phosphodiesterase; inhibitor; flavonoid; licorice root; structure activity relationship
01 Pubblicazione su rivista::01a Articolo in rivista
INHIBITORS OF CAMP PHOSPHODIESTERASE IN MEDICINAL-PLANTS .17. INHIBITION OF ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE PHOSPHODIESTERASE BY FLAVONOIDS FROM LICORICE ROOTS AND 4-ARYLCOUMARINS / A., Kusano; T., Nikaido; T., Kuge; T., Ohmoto; G., Dellemonache; Botta, Bruno; M., Botta; T., Saitoh. - In: CHEMICAL & PHARMACEUTICAL BULLETIN. - ISSN 0009-2363. - 39:(1991), pp. 930-933.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/467702
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