Enzyme-catalyzed cyclizations of synthetic dibenzylbutanolides to analogues of the podophyllotoxin family are described. The biotransformations utilize enzymes derived from Cassia didymobotrya cell cultures and previously synthesized dibenzylbutanolides which differ in functionality in order to evaluate the course of the cyclization process. The application of this methodology provides additional information relating to the utilization of such ''substrates'' in the future synthesis of the anti-cancer drug, Etoposide, via a combination of synthetic chemistry and biotechnological methods.
Studies with plant cell cultures of Cassia didymobotrya .7. Enzyme catalyzed biotransformation of dibenzylbutanolides to podophyllotoxin analogues and related compounds / Botta, Bruno; G., Dellemonache; P., Ricciardi; A., Vitali; V., Vinciguerra; Misiti, Domenico; J. P., Kutney; N., Stoynov. - In: HETEROCYCLES. - ISSN 0385-5414. - 43:(1996), pp. 2443-2456.
Studies with plant cell cultures of Cassia didymobotrya .7. Enzyme catalyzed biotransformation of dibenzylbutanolides to podophyllotoxin analogues and related compounds
BOTTA, Bruno;MISITI, Domenico;
1996
Abstract
Enzyme-catalyzed cyclizations of synthetic dibenzylbutanolides to analogues of the podophyllotoxin family are described. The biotransformations utilize enzymes derived from Cassia didymobotrya cell cultures and previously synthesized dibenzylbutanolides which differ in functionality in order to evaluate the course of the cyclization process. The application of this methodology provides additional information relating to the utilization of such ''substrates'' in the future synthesis of the anti-cancer drug, Etoposide, via a combination of synthetic chemistry and biotechnological methods.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
