Methanol extracts of the skin of Phyllomedusa sauvagei, a South American hylid frog, contain an active polypeptide, sauvagine, which has been isolated in a pure form and shown to be constituted by a straight chain of 40 amino acid residues. The polypeptide displayed in the rat an intense hypotensive action, that is probably the main cause of the intense antidiuresis observed in hydrated rats. The reduction in urine volume was accompanied by a decrease in glomerular filtration rate, and by an increase in tubular sodium and potassium reabsorption and in plasma aldosterone concentration.
The mechanism of the antidiuretic effect of sauvagine in rats / Improta, Giovanna. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 12:3(1980), pp. 185-193.
The mechanism of the antidiuretic effect of sauvagine in rats
IMPROTA, Giovanna
1980
Abstract
Methanol extracts of the skin of Phyllomedusa sauvagei, a South American hylid frog, contain an active polypeptide, sauvagine, which has been isolated in a pure form and shown to be constituted by a straight chain of 40 amino acid residues. The polypeptide displayed in the rat an intense hypotensive action, that is probably the main cause of the intense antidiuresis observed in hydrated rats. The reduction in urine volume was accompanied by a decrease in glomerular filtration rate, and by an increase in tubular sodium and potassium reabsorption and in plasma aldosterone concentration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
