Aim: The creation of a physician-administered questionnaire to screen patients with Systemic Lupus Erythematosus (SLE) for the presence of symptoms suggestive of neuropsychiatric involvement (NPSLE). Methods: The development of the questionnaire followed three phases. First, a list of manifestations was prepared based on the ACR case definitions for NPSLE. A first questionnaire was constructed including 119 items. To reduce their number, a Delphi analysis was carried out and a second questionnaire with 62 questions was developed. This questionnaire was administered to 139 patients with SLE (58 with NPSLE: 29 active, 29 inactive; and 81 without NPSLE: 39 active, 42 inactive). Questions relevant to the screening of patients were selected on the basis of the receiver operating characteristic (ROC) curve analysis. Results: Twenty-seven questions concerning central nervous system and psychiatric manifestations were found to be relevant; the remaining could be eliminated without significantly affecting AUC. The area under the ROC curve (AUC) was 0.69 (95% CI 0.61-0.78). A score above 17 was considered as suggestive of the presence of NPSLE with a sensitivity of 92.9% (95% CI 85.1-97.3 %) and specificity of 25.4% (95% CI 14.7-39.00 %). Conclusions: This questionnaire could represent a 'core set' of questions that could help in clinical practice to identify patients with neuropsychiatric symptoms requiring further evaluation. Lupus (2011) 20, 485-492.

The development of a simple questionnaire to screen patients with SLE for the presence of neuropsychiatric symptoms in routine clinical practice / M., Mosca; M., Govoni; P., Tomietto; M., Aringer; D., Boumpas; R., Cervera; Conti, Fabrizio; D., D'Cruz; A., Doria; D., De La Fuente; M., Galeazzi; F., Houssiau; T. W., Huizinga; M. A., Khamashta; L., Ines; C., Duarte; M., Couto; P., Meroni; C., Montecucco; E., Norkuviene; G., Riemekasten; V., Rios; M., Schneider; Y., Shoenfeld; G. M., Steup Beekman; M., Szmyrka Kaczmarek; C., Tani; A., Tincani; A. G., Tzioufas; R., Voll; W., Bencivelli; F., Salaffi; S., Bombardieri. - In: LUPUS. - ISSN 0961-2033. - STAMPA. - 20:5(2011), pp. 485-492. [10.1177/0961203310389097]

The development of a simple questionnaire to screen patients with SLE for the presence of neuropsychiatric symptoms in routine clinical practice

CONTI, FABRIZIO;
2011

Abstract

Aim: The creation of a physician-administered questionnaire to screen patients with Systemic Lupus Erythematosus (SLE) for the presence of symptoms suggestive of neuropsychiatric involvement (NPSLE). Methods: The development of the questionnaire followed three phases. First, a list of manifestations was prepared based on the ACR case definitions for NPSLE. A first questionnaire was constructed including 119 items. To reduce their number, a Delphi analysis was carried out and a second questionnaire with 62 questions was developed. This questionnaire was administered to 139 patients with SLE (58 with NPSLE: 29 active, 29 inactive; and 81 without NPSLE: 39 active, 42 inactive). Questions relevant to the screening of patients were selected on the basis of the receiver operating characteristic (ROC) curve analysis. Results: Twenty-seven questions concerning central nervous system and psychiatric manifestations were found to be relevant; the remaining could be eliminated without significantly affecting AUC. The area under the ROC curve (AUC) was 0.69 (95% CI 0.61-0.78). A score above 17 was considered as suggestive of the presence of NPSLE with a sensitivity of 92.9% (95% CI 85.1-97.3 %) and specificity of 25.4% (95% CI 14.7-39.00 %). Conclusions: This questionnaire could represent a 'core set' of questions that could help in clinical practice to identify patients with neuropsychiatric symptoms requiring further evaluation. Lupus (2011) 20, 485-492.
2011
clinical practice; neuropsychiatric lupus; questionnaire; screening; systemic lupus erythematosus
01 Pubblicazione su rivista::01a Articolo in rivista
The development of a simple questionnaire to screen patients with SLE for the presence of neuropsychiatric symptoms in routine clinical practice / M., Mosca; M., Govoni; P., Tomietto; M., Aringer; D., Boumpas; R., Cervera; Conti, Fabrizio; D., D'Cruz; A., Doria; D., De La Fuente; M., Galeazzi; F., Houssiau; T. W., Huizinga; M. A., Khamashta; L., Ines; C., Duarte; M., Couto; P., Meroni; C., Montecucco; E., Norkuviene; G., Riemekasten; V., Rios; M., Schneider; Y., Shoenfeld; G. M., Steup Beekman; M., Szmyrka Kaczmarek; C., Tani; A., Tincani; A. G., Tzioufas; R., Voll; W., Bencivelli; F., Salaffi; S., Bombardieri. - In: LUPUS. - ISSN 0961-2033. - STAMPA. - 20:5(2011), pp. 485-492. [10.1177/0961203310389097]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/461785
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