Differential scanning calorimetry (DSC) has been used to investigate drug-excipient interactions and, in consequence, their compatibility. In particular, binary mixtures of nefazodone with magnesium stearate and lactose, and fosinopril with the same excipients were prepared and analysed, after proper conditioning. The thermoanalytical results were compared with those obtained by spectroscopic (UV, IR) and chromatographic (HPLC) analysis. We believe that changes in DSC runs cannot always be a sufficient condition to prove that some interaction occurs between drug and excipient during storage at room temperature. Some data on the spectroscopic characteristics of nefazodone and fosinopril drugs and their thermal behaviour are also reported.
Application of differential scanning calorimetry to the study of drug-excipient compatibility / Fabrizio, Balestrieri; Magri', Andrea; Magri', Antonio; Domenico, Marini; Amalia, Sacchini. - In: THERMOCHIMICA ACTA. - ISSN 0040-6031. - STAMPA. - 285:2(1996), pp. 337-345. [10.1016/0040-6031(96)02904-8]
Application of differential scanning calorimetry to the study of drug-excipient compatibility
MAGRI', Andrea;MAGRI', Antonio;
1996
Abstract
Differential scanning calorimetry (DSC) has been used to investigate drug-excipient interactions and, in consequence, their compatibility. In particular, binary mixtures of nefazodone with magnesium stearate and lactose, and fosinopril with the same excipients were prepared and analysed, after proper conditioning. The thermoanalytical results were compared with those obtained by spectroscopic (UV, IR) and chromatographic (HPLC) analysis. We believe that changes in DSC runs cannot always be a sufficient condition to prove that some interaction occurs between drug and excipient during storage at room temperature. Some data on the spectroscopic characteristics of nefazodone and fosinopril drugs and their thermal behaviour are also reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.