The results achieved in three different studies carried out on patients affected by Hodgkin's disease are discussed. In study No. 1, 58 patients with pathological Stage I-II were treated with only a "Mantle" field irradiation. The complete remission (CR) rate was 98\% with an actuarial overall survival of 90\%, and a median of follow-up of 80 months. Thirty-one percent of patients relapsed. In study No. 2, 42 patients were randomly allocated to receive only MOPP chemotherapy versus extended field irradiation; CR rate was 68 and 95\%, respectively (p less than 0.05). The overall survival rate was 100\% in the radiotherapy group and 82\% in the MOPP group. No relapses have been observed in patients treated with MOPP. In study No. 3, 218 patients affected by advanced Stage HD were randomly treated with 6 cycles of MOPP chemotherapy versus 6 cycles of ABVD chemotherapy. In the MOPP group the CR rate, the relapse-free survival rate (RFS), and overall survival (OS) rates at 60 months were 77, 68, and 76\% respectively, whereas, in the ABVD group the CR, the RFS, and OS rates at 60 months were 75, 77 and 80\% respectively, (p less than 0.05). These data and statistical comparisons are analyzed.
Evaluation of therapeutic modalities in the control of Hodgkin's disease / Mandelli, Franco; Anselmo, Anna Paola; C., Cartoni; Cimino, Giuseppe; MAURIZI ENRICI, Riccardo; C., Biagini. - In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. - ISSN 0360-3016. - STAMPA. - 12:(1986), pp. 1617-1620. [10.1016/0360-3016(86)90287-7]
Evaluation of therapeutic modalities in the control of Hodgkin's disease.
MANDELLI, Franco;ANSELMO, Anna Paola;CIMINO, Giuseppe;MAURIZI ENRICI, Riccardo;
1986
Abstract
The results achieved in three different studies carried out on patients affected by Hodgkin's disease are discussed. In study No. 1, 58 patients with pathological Stage I-II were treated with only a "Mantle" field irradiation. The complete remission (CR) rate was 98\% with an actuarial overall survival of 90\%, and a median of follow-up of 80 months. Thirty-one percent of patients relapsed. In study No. 2, 42 patients were randomly allocated to receive only MOPP chemotherapy versus extended field irradiation; CR rate was 68 and 95\%, respectively (p less than 0.05). The overall survival rate was 100\% in the radiotherapy group and 82\% in the MOPP group. No relapses have been observed in patients treated with MOPP. In study No. 3, 218 patients affected by advanced Stage HD were randomly treated with 6 cycles of MOPP chemotherapy versus 6 cycles of ABVD chemotherapy. In the MOPP group the CR rate, the relapse-free survival rate (RFS), and overall survival (OS) rates at 60 months were 77, 68, and 76\% respectively, whereas, in the ABVD group the CR, the RFS, and OS rates at 60 months were 75, 77 and 80\% respectively, (p less than 0.05). These data and statistical comparisons are analyzed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.