Cell-mediated cytotoxic response in vitro to a Moloney strain of murine leukemia virus-induced tumor (LSTRA) altered by 5-(3,3-dimethyl-1- triazeno)imidazole-4-carboxamide (DTIC) was investigated with the use of mixed-leukocyte tumor cell cultures (MLTC). As assessed by means of a short-term 51Cr-release assay, minimal or no cytolytic activity was generated in primary MLTC. In contrast, high specific cytotoxic response against the altered tumor was obtained in secondary MLTC. Partial cross-reactivity was found between the LSTRA and LSTRA/DTIC tumor lines.
Secondary cytotoxic response in vitro against Moloney lymphoma cells antigenically altered by drug treatment in vivo / Santoni, Angela; Y., Kinney; A., Goldin. - In: JOURNAL OF THE NATIONAL CANCER INSTITUTE. - ISSN 0027-8874. - STAMPA. - 60:1(1978), pp. 109-112.
Secondary cytotoxic response in vitro against Moloney lymphoma cells antigenically altered by drug treatment in vivo
SANTONI, Angela;
1978
Abstract
Cell-mediated cytotoxic response in vitro to a Moloney strain of murine leukemia virus-induced tumor (LSTRA) altered by 5-(3,3-dimethyl-1- triazeno)imidazole-4-carboxamide (DTIC) was investigated with the use of mixed-leukocyte tumor cell cultures (MLTC). As assessed by means of a short-term 51Cr-release assay, minimal or no cytolytic activity was generated in primary MLTC. In contrast, high specific cytotoxic response against the altered tumor was obtained in secondary MLTC. Partial cross-reactivity was found between the LSTRA and LSTRA/DTIC tumor lines.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
