In this study, we showed by Northern blot analysis and bioassays that scarcely differentiated human hepatoma cell line HA22T/VGH constitutively produces interleukin-6 (IL6). This cytokine was produced neither by moderately differentiated Li7A nor by well-differentiated HepG2 human hepatoma cell lines. The finding that transcripts for IL6 were not present in 2.2.15 cells, a HepG2-derived clone transfected with the intracellular replicative form of hepatitis B virus (HBV) DNA, suggests that production of this cytokine is not affected by HBV-encoded gene products, but is more likely related to the dedifferentiated state of hepatoma cells.
INTERLEUKIN-6 PRODUCTION BY HUMAN HEPATOMA LINES IS RELATED TO A LOW DEGREE OF CELL-DIFFERENTIATION / Paroli, Marino; G., Carloni; E., Alfani; G., De Petrillo; Barnaba, Vincenzo. - In: RESEARCH IN VIROLOGY. - ISSN 0923-2516. - 144:4(1993), pp. 323-326. [10.1016/s0923-2516(06)80048-8]
INTERLEUKIN-6 PRODUCTION BY HUMAN HEPATOMA LINES IS RELATED TO A LOW DEGREE OF CELL-DIFFERENTIATION
PAROLI, Marino;BARNABA, Vincenzo
1993
Abstract
In this study, we showed by Northern blot analysis and bioassays that scarcely differentiated human hepatoma cell line HA22T/VGH constitutively produces interleukin-6 (IL6). This cytokine was produced neither by moderately differentiated Li7A nor by well-differentiated HepG2 human hepatoma cell lines. The finding that transcripts for IL6 were not present in 2.2.15 cells, a HepG2-derived clone transfected with the intracellular replicative form of hepatitis B virus (HBV) DNA, suggests that production of this cytokine is not affected by HBV-encoded gene products, but is more likely related to the dedifferentiated state of hepatoma cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
