I describe a model which posits the molecular basis of some malaria-resistance genes in the interaction between oxidized hemoglobin and membrane components The model is supported by a considerable body of evidence which indicates that erythrocytes of genetically protected individuals (carriers of sickle cell trait, α- and β-thalassemia, and G6PD deficiency) are susceptible to the increase of oxidation of hemoglobin following H2O2 release in the host cell by Plasmodium falciparum. I suggest that the irreversible interaction between oxidized hemoglobin and the red cell membrane could trigger mechanisms that: (i) reduce invasion of erythrocytes by the falciparum parasite, (ii) impair parasite survival and development within the cell, (iii) accelerate infected erythrocyte clearance by phagocytosis.

Genetic resistance to malaria, oxidative stress and hemoglobin oxidation / DESTRO-BISOL, Giovanni. - In: PARASSITOLOGIA. - ISSN 0048-2951. - STAMPA. - 41:1-3(1999), pp. 203-204.

Genetic resistance to malaria, oxidative stress and hemoglobin oxidation

DESTRO-BISOL, Giovanni
1999

Abstract

I describe a model which posits the molecular basis of some malaria-resistance genes in the interaction between oxidized hemoglobin and membrane components The model is supported by a considerable body of evidence which indicates that erythrocytes of genetically protected individuals (carriers of sickle cell trait, α- and β-thalassemia, and G6PD deficiency) are susceptible to the increase of oxidation of hemoglobin following H2O2 release in the host cell by Plasmodium falciparum. I suggest that the irreversible interaction between oxidized hemoglobin and the red cell membrane could trigger mechanisms that: (i) reduce invasion of erythrocytes by the falciparum parasite, (ii) impair parasite survival and development within the cell, (iii) accelerate infected erythrocyte clearance by phagocytosis.
1999
g6pd deficiency; alpha- and beta-thalassemia; plasmodium falciparum; malaria; hemoglobin; oxidative stress; adaptation
01 Pubblicazione su rivista::01a Articolo in rivista
Genetic resistance to malaria, oxidative stress and hemoglobin oxidation / DESTRO-BISOL, Giovanni. - In: PARASSITOLOGIA. - ISSN 0048-2951. - STAMPA. - 41:1-3(1999), pp. 203-204.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/44995
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