Previous evidence supports a role of atrial natriuretic peptide (ANP) as a candidate gene for hypertension. We characterized an ANP gene promoter variant, which has been associated with lower peptide levels, in a sample of young male subjects from Southern Italy (n=395, mean age=35.2+/-2 years) followed up for 28 years. In this cohort, the ANP gene variant was associated with early blood pressure increase and predisposition to develop hypertension.
Atrial natriuretic peptide (ANP) gene promoter variant and increased susceptibility to early development of hypertension in humans / Rubattu, Speranza Donatella; Evangelista, A; Barbato, D; Barba, G; Stanzione, R; Iacone, R; Volpe, Massimo; Strazzullo, P.. - In: JOURNAL OF HUMAN HYPERTENSION. - ISSN 0950-9240. - 21:(2007), pp. 822-824.
Atrial natriuretic peptide (ANP) gene promoter variant and increased susceptibility to early development of hypertension in humans.
RUBATTU, Speranza Donatella;VOLPE, Massimo;
2007
Abstract
Previous evidence supports a role of atrial natriuretic peptide (ANP) as a candidate gene for hypertension. We characterized an ANP gene promoter variant, which has been associated with lower peptide levels, in a sample of young male subjects from Southern Italy (n=395, mean age=35.2+/-2 years) followed up for 28 years. In this cohort, the ANP gene variant was associated with early blood pressure increase and predisposition to develop hypertension.| File | Dimensione | Formato | |
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