Lymphatic and distant metastases are primary factors in determining survival in patients with lung cancer. The identification of novel molecular biomarkers that can predict the presence of micrometastasis in lymph nodes and their incorporation in traditional histologic staging is needed. MicroRNAs are emerging as powerful biomarkers for several neoplastic disorders. This article reports the experimental results that have recently led to the identification of several microRNAs deregulated in lung cancer that are strongly associated with lymph node metastasis and advanced clinical stage. This evidence indicates that microRNAs are a promising tool for the clinical management of lung cancer.
MicroRNAs and Lymph Node Metastatic Disease in Lung Cancer / Fazi, Francesco; Giulia, Fontemaggi. - In: THORACIC SURGERY CLINICS. - ISSN 1547-4127. - STAMPA. - 22:2(2012), pp. 167-175. [10.1016/j.thorsurg.2011.11.001]
MicroRNAs and Lymph Node Metastatic Disease in Lung Cancer
FAZI, Francesco;
2012
Abstract
Lymphatic and distant metastases are primary factors in determining survival in patients with lung cancer. The identification of novel molecular biomarkers that can predict the presence of micrometastasis in lymph nodes and their incorporation in traditional histologic staging is needed. MicroRNAs are emerging as powerful biomarkers for several neoplastic disorders. This article reports the experimental results that have recently led to the identification of several microRNAs deregulated in lung cancer that are strongly associated with lymph node metastasis and advanced clinical stage. This evidence indicates that microRNAs are a promising tool for the clinical management of lung cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
