Background: Insulin pumps and real-time continuous glucose monitoring devices have recently been combined into the sensor-augmented pump (SAP) system. The objective of this study was the evaluation of the clinical use of SAP in a large series of children with type 1 diabetes using insulin pump therapy. Methods: A questionnaire was administered in all pediatric diabetologic centers in Italy; data were analyzed only regarding patients 18 years old or younger and using SAP for 6 months or more. Results: Among all patients using an insulin pump, 129 (13.5 +/- 3.8 years old, with a disease duration of 6.3 +/- 3.4 years) have been using SAP for 1.4 +/- 0.7 years. Four hundred ninety-three patients (12.9 +/- 3.4 years old, with a disease duration of 6.2 +/- 3.3 years) using conventional insulin pump therapy for 1.7 +/- 0.5 years have been evaluated as the control group. After 0.5-3 years of using SAP or conventional insulin pump therapy, glycosylated hemoglobin significantly improved (8.0 +/- 1.5% vs. 7.4 +/- 0.8% [P = 0.002] and 8.0 +/- 1.6% vs. 7.7 +/- 1.1% [P = 0.006], respectively); the improvement was higher with SAP (P = 0.005). Insulin requirement showed a significant decrease only in SAP patients (0.88 +/- 0.25 vs. 0.7 +/- 0.23 U/kg/day, P = 0.003). Body mass index did not change during the observation period. No diabetic ketoacidosis episodes were observed during the follow-up, and severe hypoglycemia significantly decreased in SAP patients (P = 0.04). Conclusions: The increased availability of continuous glucose sensors is likely to have a significant impact on pediatric diabetes therapy and education in the near future. In daily settings, patients using SAP can achieve a better control than patients using conventional insulin pump.

Use of Integrated Real-Time Continuous Glucose Monitoring/Insulin Pump System in Children and Adolescents with Type 1 Diabetes: A 3-Year Follow-Up Study / A. e., Scaramuzza; D., Iafusco; I., Rabbone; R., Bonfanti; F., Lombardo; R., Schiaffini; P., Buono; S., Toni; V., Cherubini; Valentino, Zuccotti; Diabetes Study Group Of The Italian Society Of Paediatric, Endocrinology; Diabetology, ; Sulli, Nicoletta. - In: DIABETES TECHNOLOGY & THERAPEUTICS. - ISSN 1520-9156. - 13:2(2011), pp. 99-103. [10.1089/dia.2010.0119]

Use of Integrated Real-Time Continuous Glucose Monitoring/Insulin Pump System in Children and Adolescents with Type 1 Diabetes: A 3-Year Follow-Up Study

SULLI, Nicoletta
2011

Abstract

Background: Insulin pumps and real-time continuous glucose monitoring devices have recently been combined into the sensor-augmented pump (SAP) system. The objective of this study was the evaluation of the clinical use of SAP in a large series of children with type 1 diabetes using insulin pump therapy. Methods: A questionnaire was administered in all pediatric diabetologic centers in Italy; data were analyzed only regarding patients 18 years old or younger and using SAP for 6 months or more. Results: Among all patients using an insulin pump, 129 (13.5 +/- 3.8 years old, with a disease duration of 6.3 +/- 3.4 years) have been using SAP for 1.4 +/- 0.7 years. Four hundred ninety-three patients (12.9 +/- 3.4 years old, with a disease duration of 6.2 +/- 3.3 years) using conventional insulin pump therapy for 1.7 +/- 0.5 years have been evaluated as the control group. After 0.5-3 years of using SAP or conventional insulin pump therapy, glycosylated hemoglobin significantly improved (8.0 +/- 1.5% vs. 7.4 +/- 0.8% [P = 0.002] and 8.0 +/- 1.6% vs. 7.7 +/- 1.1% [P = 0.006], respectively); the improvement was higher with SAP (P = 0.005). Insulin requirement showed a significant decrease only in SAP patients (0.88 +/- 0.25 vs. 0.7 +/- 0.23 U/kg/day, P = 0.003). Body mass index did not change during the observation period. No diabetic ketoacidosis episodes were observed during the follow-up, and severe hypoglycemia significantly decreased in SAP patients (P = 0.04). Conclusions: The increased availability of continuous glucose sensors is likely to have a significant impact on pediatric diabetes therapy and education in the near future. In daily settings, patients using SAP can achieve a better control than patients using conventional insulin pump.
2011
01 Pubblicazione su rivista::01a Articolo in rivista
Use of Integrated Real-Time Continuous Glucose Monitoring/Insulin Pump System in Children and Adolescents with Type 1 Diabetes: A 3-Year Follow-Up Study / A. e., Scaramuzza; D., Iafusco; I., Rabbone; R., Bonfanti; F., Lombardo; R., Schiaffini; P., Buono; S., Toni; V., Cherubini; Valentino, Zuccotti; Diabetes Study Group Of The Italian Society Of Paediatric, Endocrinology; Diabetology, ; Sulli, Nicoletta. - In: DIABETES TECHNOLOGY & THERAPEUTICS. - ISSN 1520-9156. - 13:2(2011), pp. 99-103. [10.1089/dia.2010.0119]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/442226
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