In this paper we report on the effects of microinjections of the mu-opioid antagonist CTOP (D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2) into the ventral tegmental area (VTA) on activity and ingestive behavior in the rat. Intra-VTA CTOP (0.015, 0.15, and 1.5 nmol per side) dose-dependently increased activity, whereas it had no effect on feeding and drinking behavior. These results are consistent with previous reports that intra-VTA injections of CTOP enhance extracellular dopamine levels in the nucleus accumbens. Furthermore, we propose a model of VTA mu-opioid mechanisms that might account for these surprising effects of intra-VTA CTOP.

INTRA-VTA INJECTIONS OF THE MU-OPIOID ANTAGONIST CTOP ENHANCE LOCOMOTOR-ACTIVITY / Badiani, Aldo; Leone, P; Stewart, J.. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 690:(1995), pp. 112-116. [10.1016/0006-8993(95)00607-R]

INTRA-VTA INJECTIONS OF THE MU-OPIOID ANTAGONIST CTOP ENHANCE LOCOMOTOR-ACTIVITY

BADIANI, Aldo;
1995

Abstract

In this paper we report on the effects of microinjections of the mu-opioid antagonist CTOP (D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2) into the ventral tegmental area (VTA) on activity and ingestive behavior in the rat. Intra-VTA CTOP (0.015, 0.15, and 1.5 nmol per side) dose-dependently increased activity, whereas it had no effect on feeding and drinking behavior. These results are consistent with previous reports that intra-VTA injections of CTOP enhance extracellular dopamine levels in the nucleus accumbens. Furthermore, we propose a model of VTA mu-opioid mechanisms that might account for these surprising effects of intra-VTA CTOP.
1995
01 Pubblicazione su rivista::01a Articolo in rivista
INTRA-VTA INJECTIONS OF THE MU-OPIOID ANTAGONIST CTOP ENHANCE LOCOMOTOR-ACTIVITY / Badiani, Aldo; Leone, P; Stewart, J.. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 690:(1995), pp. 112-116. [10.1016/0006-8993(95)00607-R]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/42918
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