The of four new carbon-carbon double bond locked analogues of strobilurins, which are characterized by a trans-1,2-disubstituted cyclopropane ring, have been synthesized according to a strategy which involves palladium-catalyzed cross-coupling reactions between methyl (Z)-2-iodo-3-methoxypropenoate and organometallic derivatives such as (1Rp,2Rp)-2-phenylcyclopropylboronic acid and (1Rp,2R)-1-(2-bromozinciophenyl)-2-arylcyclopropanes. The boronic acid has been prepared via cyclopropanation of (E)-2-phenylethenyl- 1,3,2-dioxaborinane and the organozinc compounds have been synthesized from easily available (E)-2-bromostilbenes.
“STEREOCONTROLLED SYNTHESIS OF CARBON-CARBON DOUBLE BOND LOCKED ANALOGUES OF STROBILURINS WHICH ARE CHARACTERIZED BY A TRANS-1,2-DISUBSTITUTED CYCLOPROPANE RING” TETRAHEDRON / R., Rossi; A., Carpita; A., Ribecai; Mannina, Luisa. - In: TETRAHEDRON. - ISSN 0040-4020. - ELETTRONICO. - 57:(2001), pp. 2847-2856. [10.1016/S0040-4020(01)00136-3]
“STEREOCONTROLLED SYNTHESIS OF CARBON-CARBON DOUBLE BOND LOCKED ANALOGUES OF STROBILURINS WHICH ARE CHARACTERIZED BY A TRANS-1,2-DISUBSTITUTED CYCLOPROPANE RING” TETRAHEDRON
MANNINA, LUISA
2001
Abstract
The of four new carbon-carbon double bond locked analogues of strobilurins, which are characterized by a trans-1,2-disubstituted cyclopropane ring, have been synthesized according to a strategy which involves palladium-catalyzed cross-coupling reactions between methyl (Z)-2-iodo-3-methoxypropenoate and organometallic derivatives such as (1Rp,2Rp)-2-phenylcyclopropylboronic acid and (1Rp,2R)-1-(2-bromozinciophenyl)-2-arylcyclopropanes. The boronic acid has been prepared via cyclopropanation of (E)-2-phenylethenyl- 1,3,2-dioxaborinane and the organozinc compounds have been synthesized from easily available (E)-2-bromostilbenes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
